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Description:
DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]).
Molecular weight: 62822
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
07-FEB-2006, entry version 38.
Phylogenetic order:
Archaea Euryarchaeota Methanobacteria Methanobacteriales Methanobacteriaceae Methanothermobacter.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DNLI_METTF:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U52681 | AAC44823.1 | - |
| HAMAP | MF_00407 | - | 1. |
| InterPro | IPR000977 | DNA_ligase. | |
| InterPro | IPR012309 | DNA_ligase_A_C. | |
| InterPro | IPR012310 | DNA_ligase_A_M. | |
| InterPro | IPR012308 | DNA_ligase_A_N. | |
| PANTHER | PTHR10459 | DNA_ligase.1 | 1. |
| Pfam | PF04679 | DNA_ligase_A_C | 1. |
| Pfam | PF01068 | DNA_ligase_A_M | 1. |
| Pfam | PF04675 | DNA_ligase_A_N | 1. |
| TIGRFAMs | TIGR00574 | dnl1 | 1. |
| PROSITE | PS00697 | DNA_LIGASE_A1 | 1. |
| PROSITE | PS00333 | DNA_LIGASE_A2 | FALSE_NEG. |
| PROSITE | PS50160 | DNA_LIGASE_A3 | 1. |
Keywords:
ATP-binding; Cell cycle; Cell division; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=DSM 3720 / Z-245;
RX MEDLINE=97158688; PubMed=9006048;
RA Noelling J., Reeve J.N.;
RT "Growth- and substrate-dependent transcription of the formate
RT dehydrogenase (fdhCAB) operon in Methanobacterium thermoformicicum Z-
RT 245.";
RL J. Bacteriol. 179:899-908(1997).
Feature:
CHAIN 1 557 DNA ligase.
/FTId=PRO_0000059608.
ACT_SITE 251 251 N6-AMP-lysine intermediate (By
similarity).
Comments:
-!- FUNCTION: This protein seals, during DNA replication, DNA
recombination and DNA repair, nicks in double-stranded DNA (By
similarity).
-!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) +
(deoxyribonucleotide)(m) = AMP + diphosphate +
(deoxyribonucleotide)(n+m).
-!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
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Sequence length: 557
MKELLYMELA EVYHRLESTT KRLEKTEILA ELLRSVDKEL LPDVTILMLG RVFPIWSEEE
LGVGIKLLMK AISLVVGVSM DEIEDEIREQ GDIGLASEKL FSRKTQTTFF SQPLTVEFVY
SRLKALASAS GDRAQSKKIN ILVEVLSQAK PLEARYITRT VLEELRVGVA EGIIRDAIAR
AFEVDPALVE RAHMLTNDLG MVAAVAREEG EPGLGRLNLE PGRPVKPMLA QLASSIESAI
TELGRAFCET KYDGIRVQIH RCGDEVSIFT RRLENITAAV PEILEGVEEA LPADDYIVEG
EIIVTMDGRP ASFQYILQRV RRKYDVDRLT REVPLSLFLF DVLYHRGPLI DEPLWHRREV
LESILSEIPG RVEASRMVDV GPDNLDDALW LFKESIREGH EGIMIKDTEA PYIPGIRGKK
MLKFKAEPET LDLIVVGGTY GRGKRAHLVG SYLLAVRDEK SGELKTIAHV ATGLDDQTLQ
DLSERMENLK VERRGRKIRV KPEIILEVAY SEIVRSPEYE SGYSLRFPVV KRIRDDLSPD
DIDTLGRVIS LFKQGFS