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Description:
DNA mismatch repair protein mutL.
Molecular weight: 71065
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2001, sequence version 1.
07-MAR-2006, entry version 23.
Phylogenetic order:
Bacteria Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_CLOAB:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE007692 | AAK79800.1 | - |
| PIR | E97126 | E97126. | |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE001437_GR | CAC1836.1 | |
| BioCyc | CACE1488:CAC1836-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 824 / DSM 792 / VKM B-1787;
RX MEDLINE=21359325; PubMed=11466286;
RX DOI=10.1128/JB.183.16.4823-4838.2001;
RA Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q.,
RA Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I.,
RA Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P.,
RA Daly M.J., Bennett G.N., Koonin E.V., Smith D.R.;
RT "Genome sequence and comparative analysis of the solvent-producing
RT bacterium Clostridium acetobutylicum.";
RL J. Bacteriol. 183:4823-4838(2001).
Feature:
CHAIN 1 622 DNA mismatch repair protein mutL.
/FTId=PRO_0000177940.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 622
MRINILSEDT SNKIAAGEVV ERPFSVVKEL VENSIDAGAK TINIEIENGG RTLIKVLDDG
YGIDKDDIEK AFMPHATSKI SKLQDIYSIN TLGFRGEALP SIASVSKTTL KSRTKENEFG
REISISGGSV DYIKDCGTNI GTHIEVRDLF YNVPAREKFL KSTAKEASSI SDIVNRLALA
HSEISFRLIN NGKRVITTYA TDNLIDTIRA IYGKKICDNV ISFERHTDLV SVHGYVGNAE
ISRGSRNNQS IFINKRYIKN KLITAAVENA VKSFMMINKF PFFIIFLDIF PEFVDVNVHP
TKSEVKFQNE RDIFKIIFDT VHEGIRNSLK ESFKVEALKE EEDKLFDIKE DVITKNEIKH
DDKIDGYIKK DSFPVPVQIP IDLKRPIENY DNSTKENKDR SFDDFREKDI IKETSQEKET
YDIITNKKAK FPELRVIGQF NNTYILAESF EELYIIDQHA AHEKILFEKY REDIKNKGVS
SQILITPSVV ELLPEDFIYY DENKEVFKNA GFVIEYFGDN TVAIKEVPLF LGKPLVKDLF
LEIIDNLKNM GSGETSEVKY RSIATAACKS AVKAYHELTH DEMKTLIQDL RFAEDPFNCP
HGRPTIVRLT VTDFEKKFKR IQ