|
|
|
|
|
|
Description:
DNA mismatch repair protein mutS.
Molecular weight: 99175
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-OCT-2001, sequence version 1.
07-MAR-2006, entry version 21.
Phylogenetic order:
Bacteria Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_CLOAB:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE007692 | AAK79801.1 | - |
| PIR | F97126 | F97126. | |
| HSSP | P23909 | 1OH6 | |
| GenomeReviews | AE001437_GR | CAC1837.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 824 / DSM 792 / VKM B-1787;
RX MEDLINE=21359325; PubMed=11466286;
RX DOI=10.1128/JB.183.16.4823-4838.2001;
RA Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q.,
RA Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I.,
RA Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P.,
RA Daly M.J., Bennett G.N., Koonin E.V., Smith D.R.;
RT "Genome sequence and comparative analysis of the solvent-producing
RT bacterium Clostridium acetobutylicum.";
RL J. Bacteriol. 183:4823-4838(2001).
Feature:
CHAIN 1 869 DNA mismatch repair protein mutS.
/FTId=PRO_0000115089.
NP_BIND 614 621 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 869
MSISPMMQQY LSIKENHKDC ILFFRVGDFY EMFFEDAEVA SRELELVLTG KDCGLEKRAP
MCGVPHHAYA IYASKLVSKG YKVAVAEQLE DPSLAKGIVK RDVIKVLTPG TYTDSSFLED
TKNNYIMSLF IHDKVSAMCF ADISTGEFNL TETELDFEII LNEISKFSPK ELVLQENLDD
KLVDKIRERF DVVYNRFSNE YFKEHRNENL KAQFSNYAEV NMTEGLKSCA NGLIKYIIDT
QKTALTHIDE LQKYEIVDFL SIDINSRRNL ELTETLKDKS KKGSLLWVLD KTSTAMGGRQ
IRKWIERPLI DDEKINLRLD AVEEMLTNVS YNEDLKELLK QVYDIERLAG KISSKSVNAK
EMISLRGSIE KLPAIKKLIK NFNSELLVNM ENALDDLGDI YKLLYESIND NPSLSIKEGN
IIKEGYNKDI DELRLAKSHG KQWIASLENT EREVTGIKSL KVSYNKVFGY YIEITKSNLN
LVPEGRYIRK QTLTNSERYI TPELKEMEEK ILGAEEKLVL LEYNVFCEIR ERIEKEIDRI
KGSAKILSEL DCICSFADVA RENNYCKPVI KRDGTLVIKE GRHPVVEKVI ASGNFVANDT
VINNSDNVMM LITGPNMAGK STYMRQVGLI VLMAQIGCFV PASAAEISIC DKIFTRIGAS
DDLNAGKSTF MVEMWEVSHI LKNATKNSLI LLDEVGRGTS TYDGLSIAWS VIEYICKSEN
LKCKTLFATH YHELTKLEGE IEGLKNYSIA VKKVNDDIIF LRKIISKGAD ESYGIEVAKI
AGLPEEVLVR AREILKDLEE AKPKTAENTE DKKTNIVKEE PKKDSYQIDF NYLERESILK
ELKDTEIMDM NPIECMNKLY EFIKRAKKL