Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10452
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
01-OCT-2001, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_CLOAB:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE007565 | AAK78483.1 | - |
| PIR | H96961 | H96961. | |
| GenomeReviews | AE001437_GR | CAC0503.1 | |
| BioCyc | CACE1488:CAC0503-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 1. |
| ProDom | PD000006 | ABC_transporter | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 1. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Transport; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 824 / DSM 792 / VKM B-1787;
RX MEDLINE=21359325; PubMed=11466286;
RX DOI=10.1128/JB.183.16.4823-4838.2001;
RA Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q.,
RA Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I.,
RA Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P.,
RA Daly M.J., Bennett G.N., Koonin E.V., Smith D.R.;
RT "Genome sequence and comparative analysis of the solvent-producing
RT bacterium Clostridium acetobutylicum.";
RL J. Bacteriol. 183:4823-4838(2001).
Feature:
CHAIN 1 939 UvrABC system protein A.
/FTId=PRO_0000093045.
DOMAIN 596 936 ABC transporter.
NP_BIND 32 39 ATP (Potential).
ZN_FING 252 279 C4-type.
NP_BIND 640 647 ATP (Potential).
ZN_FING 739 765 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 1 ABC transporter domain.
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Sequence length: 939
MKDKIVIKGA KVHNLKNVDL TVPRNEFVVF TGLSGSGKSS LAFDTLYAEG QRRYMESLSS
YARQFLGQMD KPNVEYIEGL SPAISIDQKT TGRNPRSTVG TVTEIYDYLR LLYAKIGVPH
CPNCGKEISQ QTVDQIVDSV MKLEERTKIQ VLAPVVRGRK GEHTKLIAHI KKSGFVRVRI
DGEVYEIDED EIKLDKNKKH HIEALVDRIV IKQGVEGRLT DSVETALKLA EGLVVINVMG
KEDMLFSENF ACPDCGISIG EISPSMFSFN APFGKCDVCD GIGTLLEIDE DLVIPDKSKS
IMEGAIAPWG EGRLKEESWT FGVLKALSKK YKLDINKPIE DYDEKTLNIL LYGAPDVLKV
NYVKDSQEMV FNHHYEGIIN QMKRRYMESN SDYIKSEIEN YMSNNPCPKC KGARLKKEVL
AITVGNKNIF EFCSMPIREE VSFIDTLELS NKHKIISAQI VKEIKSRLEF LINVGLDYLN
LAREARTLSG GESQRIRLAT QIGSSLVGVL YILDEPSIGL HQRDNDRLIA TMKNLKDIGN
TLIVVEHDED TIKAADFIVD IGPGAGEHGG EIIAAGSLED IKNCKESITG QYLTGVKKIE
VPKERREAGK NFIEIVGAKE NNLKNVNVKF PVGLFTCVTG VSGSGKSTLV NEILYKALNK
KINRSKLNPG KYKSINGIEN IDKIIDINQS PIGRTPRSNP ATYTGVFDII RELYASTKEA
KLRGYKAGRF SFNVKGGRCE ACKGDGIVRI EMQFLSDVYV PCDVCKGKRY NRETLEIKYK
DKNIDDLLNM TVEDALKFFE NLPRIKNKLQ TLADVGLGYV RLGQPSTQLS GGEAQRIKLA
YELSKRSTGK TLYILDEPTT GLHTDDVKKL ISILQRLTDM GNTVVVIEHN LDVIKCADYI
VDLGPEGGEK GGTILCSGTP EQVAQNSSSY TGQYLKKML