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Description:
DNA mismatch repair protein mutL.
Molecular weight: 77206
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_CLOPE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000016 | BAB80862.1 | - |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | BA000016_GR | CPE1156.1 | |
| BioCyc | CPER1502:CPE1156-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13 / Type A;
RX MEDLINE=21664373; PubMed=11792842; DOI=10.1073/pnas.022493799;
RA Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A.,
RA Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT "Complete genome sequence of Clostridium perfringens, an anaerobic
RT flesh-eater.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
Feature:
CHAIN 1 674 DNA mismatch repair protein mutL.
/FTId=PRO_0000177941.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 674
MNRINILNAD TANKIAAGEV VERPSSVVKE LVENSLDAGA KNITIEIQNG GESLIKIIDD
GSGVHPEDVE KAFNPHATSK IKDTYDIFSI NTLGFRGEAL PSIASIARVD FKSKTEDFDM
GKELIISGGE KESLTDCSMN RGTQIEVRDL FFNVPARKKF LKTTARESAL INDLVNRISL
ANPDVSFKLF NNNKKILNTY GNGKLIDVIR TIYGKSTAEN LIYFEEHKDT ASVYGFIGND
TLARASRNNQ SLFVNKRYVK NRSLTVAVEN AFRSFNVTGK FPFFVLFIDT YPELIDVNIH
PTKSEIKFKD ERFIFKVVFD AVHSAMREYV KDTFTLPEEE EKKFEALKEE VIQESLDKEI
STLEKLKENI NYKVSEDKKK EEIYSYNPSK DYEAKTEVNI PVDFLSKENQ DESFSINNSL
ENNEFKEVSA KREISYDPIL IKNELKDKVS ESTSESLERS DYKCNKNEYG NSIEEIIYRE
AKFPKLRVIG QFNKTYILAE YDSTLYLIDQ HAAHEKILFE KYSSDIAKKK VEIQPLMIPL
VVTLPTEDYL YYDENKEIFE KAGFKISDFG DNSIRIEEVP YFLDKLNPTE LITSMINNLK
KMGTGETVEV KYNKIASMSC RAAVKANDVL SILEMENLIE DLRYINDPFH CPHGRPTIIK
FTSYELDKKF KRIT