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Description:
DNA mismatch repair protein mutS.
Molecular weight: 10301
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_CLOPE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000016 | BAB80861.1 | - |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | BA000016_GR | CPE1155.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13 / Type A;
RX MEDLINE=21664373; PubMed=11792842; DOI=10.1073/pnas.022493799;
RA Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A.,
RA Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT "Complete genome sequence of Clostridium perfringens, an anaerobic
RT flesh-eater.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
Feature:
CHAIN 1 909 DNA mismatch repair protein mutS.
/FTId=PRO_0000115090.
NP_BIND 615 622 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 909
MKLTPMMRQY FEIKENYKDC ILFFRLGDFY EMFFEDAETA ARELELVLTG RDCGLEKRAP
MCGIPFHASN SYIGRLVAKG YKVAICEQVE DPKVAKGIVK RDVIKVITPG TYTDSSFVEE
TKNNYIMTIY SDLERNRCSL AITDISTGDF LATEGELEKG VILDEISKFN PKEIILLDSL
DQELIKDITL TTPALISRKP IEYFEEKFEE VLNAQFGEKS NSLSLMVKKS SNALVKYILD
TQKISLTNIN DIEVYSLVDF MTIDLSSRRN LELTENLREK SKKGSLLWVL DKTETSMGSR
MLRRWIEEPL VNKEKITLRL NAVEELFNDL SLNDSLKEAL HDIYDIERIL GKISNKNANA
KDLIALKTSI GKIPNVKGII ENCTSSLLRN YHHNLDDLRD IYELLEKSIK EDPSLTLKDG
DLIKDGFNSE IDELRLAKTN GKDWISSLEN REREFTGIKS LKVGFNKVFG YYIEISKANY
SSIPEGRYIR KQTLANAERF ITPELKEIEE KLLGASEKLC SLEYDIFLDI RNEVENHIDR
LKTTAKIIAE LDCISNLAFV ALENDFIKPE INEDGETKIE NGRHPVVEKV IPKGEFIPND
TIINKDDNQL LIITGPNMAG KSTYMRQVAI ITLMCQIGSF VPASKANISV VDKIFTRIGA
SDDLAGGKST FMVEMWEVSN ILKNATENSL VLLDEVGRGT STYDGLSIAW SVIEYICKNK
NLRCKTLFAT HYHELTKLEG EIHGVRNYSV AVKEVDNNII FLRKIIEGGA DQSYGIEVAK
LAGIPDDVIN RAKEILEKLE MESSKDNLDL ALKEVNASKE EMKEASITSS YEVKETLVEE
DKIEIKEEVI SKASEAKTHK EDDQIQLDFS AIGKDNLIKE LSEVDILSLN PMEAMNRLYA
LVKEAKNLI