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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10472
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 24.
Phylogenetic order:
Bacteria Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_CLOPE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000016 | BAB80054.1 | - |
| GenomeReviews | BA000016_GR | CPE0348.1 | |
| BioCyc | CPER1502:CPE0348-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 1. |
| ProDom | PD000006 | ABC_transporter | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 1. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 2. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Transport; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13 / Type A;
RX MEDLINE=21664373; PubMed=11792842; DOI=10.1073/pnas.022493799;
RA Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A.,
RA Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT "Complete genome sequence of Clostridium perfringens, an anaerobic
RT flesh-eater.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
Feature:
CHAIN 1 939 UvrABC system protein A.
/FTId=PRO_0000093046.
DOMAIN 337 594 ABC transporter 1.
DOMAIN 599 936 ABC transporter 2.
NP_BIND 32 39 ATP (Potential).
ZN_FING 252 279 C4-type.
NP_BIND 640 647 ATP (Potential).
ZN_FING 739 765 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 939
MKDKIIVKGA KVHNLKNVSL EIPRDKLIVF TGLSGSGKSS LAFDTIYAEG QRRYVESLSS
YARQFLGQMD KPDVESIEGL SPAISIDQKT TSRNPRSTVG TVTEIYDYLR LLYARVGVPH
CPKCGKEITQ QSVDQIVDQI MELPERSKIM ILAPIIRGRK GTHEKVLENI KKQGFVRARI
DGEIYDLTED EIKLEKNIKH NIEAVVDRII VKDGIEGRLT DSIETSLKMA EGLVLVNIIG
EEDRLYSEHF ACADCGISID ELAPRMFSFN SPFGKCERCD GLGTLMEIDE DLVVPNKDLS
IRGGAISTWG DSRMKEESWT YCVLKALMEK YNFDLDTPYK DLPKKVQEVL MYGEPEKLKV
TYTKENVTAV YNHSFEGEIN NLRRRYMETN SDTMKAEIEK YMSDNPCPKC KGARLKPEAL
AVTVGGKNIF EFTSMAIREE LDFINSINFS EKDKIISSQI IKEIQSRLSF LINVGLDYLD
LARKAGTLSG GEAQRIRLAT QIGSQLMGVL YILDEPSIGL HQRDNDRLIS TLKQLRDVGN
TLIVVEHDED TMREADYIVD IGPGAGEHGG KIVASGTLDE IMSNENSLTG KYLTGAKKVE
LPEERRKGNG NFITVKGAKE NNLKNVTAKF PLGTLTMVTG VSGSGKSTLV NEILYKGLNK
IVNKAKDLPG KFKEITGYEN IDKIIDIDQS PIGRTPRSNP ATYTGTFDII RELFSQTQEA
KMRGYKPGRF SFNVKGGRCE ACSGDGIIKI EMQFLSDVYV PCEVCKGKRY NRETLEVKYK
GKNIADVLNM TVEEALEFFE NIPRIKNKLQ TLMDVGLGYI RLGQPSTQLS GGEAQRIKLA
YELSKRSTGK TLYILDEPTT GLHIHDVNRL VKILQRLVDG GNTVIVIEHN LDMIKCADYI
VDLGPEGGDK GGTIIATGTP EKIAGAKESY TGKYLKKYL