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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 71391
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 21.
Phylogenetic order:
Bacteria Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_CLOPE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000016 | BAB80058.1 | - |
| GenomeReviews | BA000016_GR | CPE0352.1 | |
| BioCyc | CPER1502:CPE0352-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR001679 | DNAligase. | |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| PANTHER | PTHR11107 | DNAligase.1 | 1. |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13 / Type A;
RX MEDLINE=21664373; PubMed=11792842; DOI=10.1073/pnas.022493799;
RA Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A.,
RA Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT "Complete genome sequence of Clostridium perfringens, an anaerobic
RT flesh-eater.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
Feature:
CHAIN 1 620 UvrABC system protein C.
/FTId=PRO_0000138298.
DOMAIN 204 239 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 620
MFDFQHQLKI LPDKPGVYIM KNSLGEVIYV GKAKVLKNRV RQYFQNSKNH SEKVRAMVKN
IAEFEYIVTD SEMEALILEC NLIKKYSPRY NIALKDDKFY PFIKITTNED FPRVYVTRNF
AKDGNRYFGP YTNGTAVYEV MGLIKKLFPL RTCKKAIVEG GEPTRACLNY HINLCKAPCA
GYISKAEYWE MIDEIINILN GTDTSIIKKL KLEMEKAAEE LEFEKAAKIR DRILAIELIS
EKQKMFTVKE GDEDFIDLYT DEKDGCAQVF FVREGKVTGR EHFMIENIGD DPVKEVISSF
IASFYGGTAQ IPKTIYVPEE IEDQELIEKF LTEKRGSKVW IKVPKKGDKK NLLDMVRNNA
KIMLDQFKEK MVEEKELNKS ALTELADVLG LDSLPVRIEA YDISNIQGVD SVGTMVVFEN
GKAKNSDYRR FKIKSVKGPN DYESMREILS RRFSHGLEEV NKIKERNLEY SNGKFCIFPD
LIMMDGGKGQ VNIALEVLKG FGIEIPVCGL VKDHKHRTRG IILNNEEILI RRGSGLMNLI
TRVQDEVHRY AITYHRSLRD KRTLHSILED IPRIGEKRRR NLLMKFGSID NIKKASMEEL
LDTPGIDKRA AESIKQYFSS