|
|
|
|
|
|
Description:
UV DNA damage endonuclease (EC 3.-.-.-) (UV-endonuclease) (UVED).
Molecular weight: 48463
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 ) pyrimidine dimer repair( GO:0006290 )
Important dates:
06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 20.
Phylogenetic order:
Bacteria Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVSE_CLOPE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000016 | BAB81778.1 | - |
| GenomeReviews | BA000016_GR | CPE2072.1 | |
| BioCyc | CPER1502:CPE2072-MONOMER | -.1 | |
| HAMAP | MF_00606 | - | 1. |
| InterPro | IPR004601 | UvdE. | |
| Pfam | PF03851 | UvdE | 1. |
| TIGRFAMs | TIGR00629 | uvde | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13 / Type A;
RX MEDLINE=21664373; PubMed=11792842; DOI=10.1073/pnas.022493799;
RA Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A.,
RA Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT "Complete genome sequence of Clostridium perfringens, an anaerobic
RT flesh-eater.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
Feature:
CHAIN 1 412 UV DNA damage endonuclease.
/FTId=PRO_0000215035.
Comments:
-!- FUNCTION: Component in a DNA repair pathway. Removal of UV-light
damaged nucleotides. Recognizes pyrimidine dimers and cleave a
phosphodiester bond immediately 5' to the lesion (By similarity).
-!- SIMILARITY: Belongs to the uve1/uvsE family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 412
MKIGYACTPI TTNARTNRRI LLKDFSKDKF LSITKQNLDD LQKILEWNIK NNIYLFRIGS
DIIPLGSHEI NNISWQKEFK DKLETIGTFI KNNKIRVSMH PGQYTVINTP KEDVLYKSIK
DIEYHCEFLD SLKVDYKNKI ILHIGGVYGD KKLAKENFLK GFKKLSDSSK KRLVIENDER
NFSLDDVLDI SSKLNIPVIF DNLHNICYGD NSYSLKEIYS LVIKTWNKEL DGNMKVHYSE
QDIFKKKGSH SPSISINSFL EYYEEIKEFS PDIMLEVKDK DISAIKCINS LKEINKTLNS
KAYREEIENY KLLLLQHDKD FQKKLNSFSK DLIEFYNYLD KLLLSPKDII GFKYSLELAF
NILKDRISNR ESLYFKKLIN EKEYEKAKVY LTKLVKKIEF PPKELSYYIS QS