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Description:
DNA mismatch repair protein mutS.
Molecular weight: 10022
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
07-MAR-2006, entry version 21.
Phylogenetic order:
Bacteria Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_CLOTE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE015927 | AAO35868.1 | - |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | AE015927_GR | CTC01302.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 2. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Massachusetts / E88;
RX MEDLINE=22457253; PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H.,
RA Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A.,
RA Gottschalk G.;
RT "The genome sequence of Clostridium tetani, the causative agent of
RT tetanus disease.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
Feature:
CHAIN 1 881 DNA mismatch repair protein mutS.
/FTId=PRO_0000115091.
NP_BIND 612 619 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 881
MKLTPMMQQY LEVKEKCKDC ILFFRLGDFY EMFFEDAETA SKELELVLTG RDCGLSKRAP
MCGIPYHSAS NYINRLVSKG YKIAICEQLE DPSAAKGIVK RDIVKIVTPG TYSDSNFLNE
TKNNYIMSLY IEDKSVAMCF CDISTGDFFA TSHSLDKSII LDEISKFDPS ELLLNKDIDK
NILKEIKNRF TISITNLEKD YFKDYNLLEG QFSDFSKEEY SLVLIKCGNG LLKYILETQK
MSLGHIDCFK NYNIVDYLSM DINSRRNLEI TETIRDKSRK GSLLWVLDKC STAMGARLIR
NWVEQPLINK EKIDKRLNAV EELVLNISLH EDLKDALKDI YDIQRIVGKI SSKNVNAKEL
LSLKNSIEKL PYIKDILSKL EADLFKDMLS NLDELKDIYE LLESSIMDNP PITIKDGNLI
KNGFNKEIDE LRMAKSHGKE WIANLESSER EFTGIKSLKV GYNKVFGYFI EVTKSNISSV
PEGRYVRKQT LSNCERYITP ELKEMEDKIL GAEEKLISLE YEVFVSIRNS IEKDIDRMKI
SANIVAILDC LSSLSTVALE NNYSKPKILE GNDIIIKDGR HPVVEKMIPT GSFVANDTTM
DTEDNQMLLI TGPNMAGKST YMRQVALITI MAQIGSFVPA KEASISLCDK IFTRIGASDD
LSAGKSTFMV EMWEVSNILK NATSKSLIIL DEVGRGTSTF DGLSIAWAVI EYICNNKNLR
SKTLFATHYH ELIQLENKIK GVKNYSVSVK EMDKDIVFLR KIIEGGADQS YGIEVAKLAG
LPEDVIIRAK EILNSIEQNK DNKIELDDIK ENKNHIEKEN KKEIATDKLL ANDDFQISFT
QIEEENLIKE ISSIDILNLN PMEGFNKLYD LINKAKSIEK K