Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 72076
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
16-JUN-2003, sequence version 1.
07-MAR-2006, entry version 19.
Phylogenetic order:
Bacteria Firmicutes Clostridia Clostridiales Clostridiaceae Clostridium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_CLOTE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE015927 | AAO36960.1 | - |
| GenomeReviews | AE015927_GR | CTC02497.1 | |
| BioCyc | CTET212717:CTC02497-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Massachusetts / E88;
RX MEDLINE=22457253; PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H.,
RA Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A.,
RA Gottschalk G.;
RT "The genome sequence of Clostridium tetani, the causative agent of
RT tetanus disease.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
Feature:
CHAIN 1 622 UvrABC system protein C.
/FTId=PRO_0000138299.
DOMAIN 204 239 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 622
MFDFEYQLKV LPEKPGVYLM KNSSDEVIYV GKAKILKNRV KQYFQQSKNH SEKVRVMVSN
IAEFEYIITD SEMEALILEC NLIKKYRPKY NILLKDDKGY PYIKITINED FPRVFISRTI
AKDGSRYFGP YTDYSAVRET IELIKKIFPI RSCKRYIRDG QKPTRPCLNY HIKLCSAPCG
AHISKQGYAL IINDIVQLLS GKDKDILDKL KNQMEEASNS LQFEKAASLR DKIFAVKKIT
EKQKIIMGSF QNEDYINIAK DEKDSCVQVF FVREGKIIGR EHFILEYTSD EREYKIIAEF
IKDFYGGAAF VPKTVYVPDI EDKYLLEQWL TIRRGSKVEI KVPKRGEKIE LLNLVKKNAK
LTLEQFKIKY LQDKALYEVA LAELSDILGF DDMPNRIEAY DISNIQGVDS VGSMVVFEKG
RSKKSDYRRF KIKTVEGAND YHSMREILRR RFQRGIEEIQ QIQKRNLEFS SGKFSVFPDL
ILIDGGKGHV NIALEVLKEL NIEIPVAGMV KDDSHTTRGI IYNNIEKDIS LDSNAMKLIT
RIQDEVHRFA ISYHRTLRDK RVLKSILDDI PNIGTIRKKE LLKKFGSIES IKKASIDQLL
ETPSIDKRSA LSIKEFFAPN EL