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Description:
Holliday junction ATP-dependent DNA helicase ruvB (EC 3.6.1.-).
Molecular weight: 38631
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
07-MAR-2006, entry version 20.
Phylogenetic order:
Bacteria Actinobacteria Actinobacteridae Actinomycetales Corynebacterineae Corynebacteriaceae Corynebacterium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVB_COREF:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000035 | BAC18583.1 | - |
| HSSP | Q56313 | 1IN4 | |
| GenomeReviews | BA000035_GR | CE1773.1 | |
| HAMAP | MF_00016 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003959 | AAA_ATPase_centr. | |
| InterPro | IPR004605 | RuvB. | |
| InterPro | IPR008823 | RuvB_C. | |
| InterPro | IPR008824 | RuvB_N. | |
| InterPro | IPR011991 | Wing_hlx_DNA_bd. | |
| Pfam | PF00004 | AAA | 1. |
| Pfam | PF05491 | RuvB_C | 1. |
| Pfam | PF05496 | RuvB_N | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00635 | ruvB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YS-314 / AJ 12310 / DSM 44549 / JCM 11189;
RX MEDLINE=22723752; PubMed=12840036; DOI=10.1101/gr.1285603;
RA Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E.,
RA Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K.,
RA Gojobori T.;
RT "Comparative complete genome sequence analysis of the amino acid
RT replacements responsible for the thermostability of Corynebacterium
RT efficiens.";
RL Genome Res. 13:1572-1579(2003).
Feature:
CHAIN 1 360 Holliday junction ATP-dependent DNA
helicase ruvB.
/FTId=PRO_0000165523.
NP_BIND 82 89 ATP (Potential).
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing (By similarity).
-!- SUBUNIT: Forms a complex with ruvA (By similarity).
-!- SIMILARITY: Belongs to the ruvB family.
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Sequence length: 360
MERTEFEIPG GIPPRRHGGT GRDPDTSVDA NIQPDDVEAE VTLRPRSLDE FIGQPKVRDQ
LSLVLTGAKK RGVVPDHVLL SGPPGLGKTT MAMIIAQELG TSLRMTSGPA LERAGDLAAM
LSNLMEGDVL FIDEIHRIAR PAEEMLYMAM EDFRIDVIVG KGPGATSIPL EIPPFTLVGA
TTRSGMLTGP LRDRFGFTAQ MEFYDVADLT RVVKRTARIL EVGIDADAAV EIASRSRGTP
RIANRLLRRV RDFAEVHADG HITLGAANAA LIVFDVDELG LDRLDRAVLD ALVRGHGGGP
VGVNTLAVAV GEEPATVEEV CEPYLVRAGM IARTGRGRVA TAAAWRHLGL EPPEGTIGDY