|
|
|
|
|
|
Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 26326
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Actinobacteria Actinobacteridae Actinomycetales Corynebacterineae Corynebacteriaceae Corynebacterium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_COREF:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000035 | BAC18246.1 | - |
| HSSP | P13051 | 1AKZ | |
| GenomeReviews | BA000035_GR | CE1436.1 | |
| BioCyc | CEFF196164:CE1436-MONOMER | -.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR003250 | U_glycsylse_pox. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| ProDom | PD011327 | U_glycsylse_pox | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YS-314 / AJ 12310 / DSM 44549 / JCM 11189;
RX MEDLINE=22723752; PubMed=12840036; DOI=10.1101/gr.1285603;
RA Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E.,
RA Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K.,
RA Gojobori T.;
RT "Comparative complete genome sequence analysis of the amino acid
RT replacements responsible for the thermostability of Corynebacterium
RT efficiens.";
RL Genome Res. 13:1572-1579(2003).
Feature:
CHAIN 1 238 Uracil-DNA glycosylase.
/FTId=PRO_0000176087.
ACT_SITE 81 81 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 238
MPVDEQPTTP EAVQWRTIED LPIHPSWRKV LEPVMDQIRD LGQFLTAETQ AGRGFLPPEP
DIFRAFSYPF EEVKVLILGQ DPYPTPGHSM GLCFSTQPGV RPLPRSLVNI FKEMATDLGV
SINATDGDLR PWSRQGVMLL NRVLTVQPGN SNSHKGRGWE AVTEAAITAL GQRDQPLVAI
LWGRQAQAVQ KFLGDTPCIT SAHPSPLSAS RGFFGSRPFS TTNRMLDDLG ATPVDWRL