Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 26076
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
20-JUN-2003, sequence version 1.
07-MAR-2006, entry version 21.
Phylogenetic order:
Bacteria Firmicutes Lactobacillales Lactobacillaceae Lactobacillus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_LACPL:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL935254 | CAD63392.1 | - |
| HSSP | P12295 | 1UUG | |
| GenomeReviews | AL935263_GR | lp_0806.1 | |
| BioCyc | LPLA220668:LP_0806-MONOMER | -.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCIMB 8826 / WCFS1;
RX MEDLINE=22480296; PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D.,
RA Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M.,
RA Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A.,
RA Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B.,
RA De Vos W.M., Siezen R.J.;
RT "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
Feature:
CHAIN 1 230 Uracil-DNA glycosylase.
/FTId=PRO_0000176108.
ACT_SITE 65 65 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 230
MKAFIHTDWW DVLKPEFEKP YYHQLHEFLK NEYRTKNIHP DMYNIFQAFE WTPFADTKVV
ILGQDPYHGP GQAHGLSFSV LPGVAVPPSL VNIYKELQDD VGCTPVNHGY LESWAKQGVL
LLNSVLTVQN GVAFSHAGKG WERLTDVAIQ RLSERSTPVV FILWGKAARS KIKLIDTQTN
VVLQAPHPSP LSAYRGFFGS KPFSKTNIAL TSFGEQPINW QLPEHVNLEH