Protein data for UVRC_LACPL:

Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).

Molecular weight: 68699

View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):

DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )


Important dates:
31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
07-MAR-2006, entry version 18.

Phylogenetic order:
Bacteria Firmicutes Lactobacillales Lactobacillaceae Lactobacillus.

To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html

Links to references in other databases for protein UVRC_LACPL:

DatabasePointerAdd. info#1Add. info#2
EMBLAL935258CAD64473.1-
GenomeReviewsAL935263_GRlp_2109.1
BioCycLPLA220668:LP_2109-MONOMER-.1
HAMAPMF_00203-1.
InterProIPR001943UvrB/C.
InterProIPR004791UvrC_ABC.
InterProIPR001162UvrC_C.
InterProIPR000305UvrC_N.
PfamPF01541GIY-YIG1.
PfamPF02151UVR1.
ProDomPD005870UvrC_C1.
SMARTSM00465GIYc1.
TIGRFAMsTIGR00194uvrC1.
PROSITEPS50151UVR1.
PROSITEPS50164UVRC_11.
PROSITEPS50165UVRC_21.

General information about the databases mentioned above

Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.

References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCIMB 8826 / WCFS1;
RX MEDLINE=22480296; PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D.,
RA Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M.,
RA Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A.,
RA Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B.,
RA De Vos W.M., Siezen R.J.;
RT "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).

Feature:
CHAIN 1 604 UvrABC system protein C.
/FTId=PRO_0000138308.
DOMAIN 197 232 UVR.

Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 604

     MASAHIEHKL SLLPDLPGCY LMKNLNSQII YVGKAKNLKN RVRSYFKSSH TGKTARLVSE
     IADFEFIVTS TDKEAFLLEI TLIQKHQPYF NIKLKKGTGY PYIKITNERD PQILIVSDVR
     KDGGYYFGPY PNVYAAQETV NFIQKVYPLR RCHGFQKRPC LYYHMGQCLG ACFKTVPVAE
     YDAQIKRIKS FLNGHVETVK KQLTKRMDQA AADLEFERAA ELRDQLNYIE MTVEKQKIIS
     NDNTPRDLFN FYLDKGWLSI QVFFIRQARL MKREKRLFPV VSTAPEEMTS FILQFYNRKN
     NVLPREVLVP NGLDKQVLSD ILGIPVRTPQ RGQKKDLLDM AQKNARIVLE EKFRLLELDE
     RKTTGAMQEI TDALGIPAGH KIEAFDHSHI QGADLVSAMV VFTDGQPNKK LYRKYKLRTV
     DHADEAASTR EVIRRRYTRL LKEHAALPDL ILMDGGEIQL EAAKDVLENE LGIATPVAAM
     VKNDHHKTAD LLASAGDQHL HLDPKSQGFY LLQRIQDEVH RFAITFHRQV HTKHSLSSRL
     DEIPGVGPKT RNKLLRKFGS MSKIAGASLE EIQSLGIAKN VAQTVKFSLA GGGVTPKHYQ
     KGAT