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Description:
DNA mismatch repair protein mutL.
Molecular weight: 69745
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
07-MAR-2006, entry version 17.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_PSEPK:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE015451 | AAN70463.1 | - |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE015451_GR | PP4896.1 | |
| TIGR | PP4896 | -. | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=22423060; PubMed=12534463;
RX DOI=10.1046/j.1462-2920.2002.00366.x;
RA Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H.,
RA Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M.,
RA Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F.,
RA Madupu R., Nelson W.C., White O., Peterson J.D., Khouri H.M.,
RA Hance I., Chris Lee P., Holtzapple E.K., Scanlan D., Tran K.,
RA Moazzez A., Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D.,
RA Wedler H., Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S.,
RA Kiewitz C., Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B.,
RA Fraser C.M.;
RT "Complete genome sequence and comparative analysis of the
RT metabolically versatile Pseudomonas putida KT2440.";
RL Environ. Microbiol. 4:799-808(2002).
Feature:
CHAIN 1 632 DNA mismatch repair protein mutL.
/FTId=PRO_0000177959.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 632
MSGGSRIQLL SPRLANQIAA GEVVERPASV AKELLENSLD SGARRIDIEV EQGGVKLLKV
RDDGSGISAD DLPLALARHA TSKIRELEDL EGVLSLGFRG EALASISSVA RLTLTSRTAS
ASEAWQVETE GRDMTPRVQP AAHPVGTSVE VRDLFFNTPA RRKFLKAEKT EFDHLQEVIR
RLALARFDVG FHLRHNGKSI LSLHEAHDEI ARARRVGAIC GPGFMEQALP IDVERNGLRL
WGWVGLPTFS RSQADLQYFF VNGRAVRDKL VAHAVRQAYR DVLFNGRHPT FVLFLELEPN
GVDVNVHPTK HEVRFREGRS VHDFLYGTLH RALADVRPED QLAAPAAVPE LVRPTGQQAG
EFGPQGEMRL ASPVLEQPRA PQQSFSNGGS GAGYQYQYTP RPSQPLPAAE AQAVYREFYK
PLETGAAPAT ALPESQGDIP PLGYALAQLK GIYILAENAV GLVLVDMHAA HERIMYERLK
VAMASEGLSG QPLLVPETLA LSQREADCAE EHAQWFQRLG FELQRLGPET LAIRQIPALL
KQAEANRLVQ DVLADLMEYG TSDRIQAHLN ELLGTMACHG AVRANRRLAI PEMNALLRDM
ENTERSGQCN HGRPTWTQMG LDDLDKLFLR GR