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Description:
Holliday junction ATP-dependent DNA helicase ruvA (EC 3.6.1.-).
Molecular weight: 22384
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
07-MAR-2006, entry version 25.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVA_PSEPK:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE015451 | AAN66840.1 | - |
| HSSP | P08576 | 1CUK | |
| GenomeReviews | AE015451_GR | PP1216.1 | |
| TIGR | PP1216 | -. | |
| HAMAP | MF_00031 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR012340 | OB_NA_bd_sub. | |
| InterPro | IPR000085 | RuvA. | |
| InterPro | IPR011114 | RuvA_C. | |
| Pfam | PF00633 | HHH | 2. |
| Pfam | PF07499 | RuvA_C | 1. |
| Pfam | PF01330 | RuvA_N | 1. |
| ProDom | PD006268 | RuvA | 1. |
| SMART | SM00278 | HhH1 | 2. |
| TIGRFAMs | TIGR00084 | ruvA | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=22423060; PubMed=12534463;
RX DOI=10.1046/j.1462-2920.2002.00366.x;
RA Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H.,
RA Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M.,
RA Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F.,
RA Madupu R., Nelson W.C., White O., Peterson J.D., Khouri H.M.,
RA Hance I., Chris Lee P., Holtzapple E.K., Scanlan D., Tran K.,
RA Moazzez A., Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D.,
RA Wedler H., Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S.,
RA Kiewitz C., Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B.,
RA Fraser C.M.;
RT "Complete genome sequence and comparative analysis of the
RT metabolically versatile Pseudomonas putida KT2440.";
RL Environ. Microbiol. 4:799-808(2002).
Feature:
CHAIN 1 205 Holliday junction ATP-dependent DNA
helicase ruvA.
/FTId=PRO_0000094666.
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing. RuvA stimulates, in the presence of DNA, the weak
ATPase activity of ruvB (By similarity).
-!- SUBUNIT: Forms a complex with ruvB.
-!- SIMILARITY: Belongs to the ruvA family.
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Sequence length: 205
MIGRLRGTLA EKQPPHLIID VNGVGYELEV PMTTLYRLPK VGETVTVHTH LVVREDAHLL
YGFAEKRERE LFRELIRLNG VGPKLALALM SGLEVDELVR CVQAQDTSAL VRVPGVGKKT
AERLLVELKD RFKAWETSPA MFTLVSDGPL PVASESSAEA DAVSALVSLG YKPQEASKAI
AAIKDKAGLS SEELIRRSLK GMISK