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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10437
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
07-MAR-2006, entry version 20.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_PSEPK:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE015451 | AAN66113.1 | - |
| GenomeReviews | AE015451_GR | PP0483.1 | |
| TIGR | PP0483 | -. | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 2. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 2. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=22423060; PubMed=12534463;
RX DOI=10.1046/j.1462-2920.2002.00366.x;
RA Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H.,
RA Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M.,
RA Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F.,
RA Madupu R., Nelson W.C., White O., Peterson J.D., Khouri H.M.,
RA Hance I., Chris Lee P., Holtzapple E.K., Scanlan D., Tran K.,
RA Moazzez A., Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D.,
RA Wedler H., Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S.,
RA Kiewitz C., Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B.,
RA Fraser C.M.;
RT "Complete genome sequence and comparative analysis of the
RT metabolically versatile Pseudomonas putida KT2440.";
RL Environ. Microbiol. 4:799-808(2002).
Feature:
CHAIN 1 944 UvrABC system protein A.
/FTId=PRO_0000093080.
DOMAIN 309 592 ABC transporter 1.
DOMAIN 605 936 ABC transporter 2.
NP_BIND 31 38 ATP (Potential).
ZN_FING 253 280 C4-type.
NP_BIND 639 646 ATP (Potential).
ZN_FING 739 765 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 944
MDKILIRGAR THNLKNIDLT LPRDKLIVIT GLSGSGKSSL AFDTLYAEGQ RRYVESLSAY
ARQFLSMMEK PDVDTIEGLS PAISIEQKST SHNPRSTVGT ITEIYDYLRL LYARVGTPRC
PDHDIPLEAQ TISQMVDLVL ERPEGSKLML LAPVVRERKG EHLAVFDELR AQGFVRARVN
GKLYELDELP KLDKQKKHSI DVVVDRFKVR ADLQQRLAES FETALKLADG IALVAPMDDE
QGEETIFSAR FACPVCGHAI SELEPKLFSF NNPAGACPTC DGLGVKQFFD TKRLVNTELT
LAEGAIRGWD RRNVYYFQML GSLAAHYGFS LEEPFGELSA EHQKVILQGS GKQSVDFKYL
NDRGDIVKRS HPFEGIVPNL ERRYRETESA TVREELAKFL GTQPCPDCRG TRLRREARHV
WVGEKTLPAV TNLPIGEASN YFGQLTLTGR RGEIAAKILK EICERLQFLV NVGLDYLTLD
RSADTLSGGE AQRIRLASQI GAGLVGVMYI LDEPSIGLHQ RDNDRLLATL NHLRDLGNTV
IVVEHDEDAI RLADYVVDIG PGAGVHGGQI VAEGSPQEVM DHPDSLTGKY LSGRKKIVVP
AKRTPRNKKL QLKLKGARGN NLQNVDLEVP IGLLTCVTGV SGSGKSTLIN NTLYPLAATA
LNGASSLEAA PHSSMDGLQH LDKVVDIDQS PIGRTPRSNP ATYTGIFTPI RELFSGVPES
RSRGYGPGRF SFNVKGGRCE ACQGDGLIKV EMHFLPDIYV PCDVCKSKRY NRETLEIKYK
GKNIHEVLEM TIEDAREFFD AVPALARKLQ TLMDVGLSYI KLGQSATTLS GGEAQRVKLS
RELSKRDTGK TLYILDEPTT GLHFADIQQL LDVLHRLRDH GNTVVVIEHN LDVIKTADWL
VDLGPEGGSK GGQIIACGTP EELSEMKQSY TGHYLKPLLE RDRA