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Description:
DNA mismatch repair protein mutL.
Molecular weight: 68496
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 2.
07-MAR-2006, entry version 32.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Treponema.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_TREPA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000520 | AAC65291.1 | ALT_INIT |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE000520_GR | TP0303.1 | |
| TIGR | TP0303 | -. | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX MEDLINE=98332770; PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M.,
RA Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D.,
RA Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M.,
RA Weidman J.F., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis
RT spirochete.";
RL Science 281:375-388(1998).
Feature:
CHAIN 1 620 DNA mismatch repair protein mutL.
/FTId=PRO_0000177988.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 620
MHETSYKPIH RLSPDTAKKI AAGEVIERPA SVVRELLENA LDAGATKIHL EINAGGCALI
RVSDNGHGMS PQDLLLCAEA HTTSKISSAD DLLQLRTLGF RGEALASIAA VSRLHLTSTR
SGPLAWHYQP KAAGTAAHVP PVPQGTEAGV LEPASLERGT VVRVEQLFEN FPARKRFLGR
QSAETTLCRS ALIDVSLAHH PVEFRFTVDG THKLTLLSQQ TRKDRCLETQ MLKGDPALFH
TIEGGDCSFH FHLVLSEPAI CRRERRGIFT FVNGRRIFDY GLVQALVLGS EGYFPNGTFP
VACLFLTVNS ERIDFNIHPA KKEVHLQDYA HIRHTLSRSV AHFYRQCTIA HYVRAEPAHA
PATQGNAPTH SSPPCTGVRE EPAAPCAHTP RYESLFPLPV QHAHLLPPSP PHISCEHARD
CTHPAPAAEG DAPVHNHTHT GAFKVLGQVA GTFIAVERNN ALYLIDQHAA HERIIFDTLQ
RNLGTAQILL IPYHIHPRSD EEARIMHRAC TELSPAGFRF HEEPDGSWHV TAVPLHWRGS
EEQLAHDILY SGKNAHDILR HVLATCACRS ACKDGTILDD ATLHSLVEQA FALPQSRCPH
GRPIWIVIGR DELFKRIKRT