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Description:
DNA mismatch repair protein mutS.
Molecular weight: 99705
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
07-MAR-2006, entry version 35.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Treponema.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_TREPA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000520 | AAC65315.1 | - |
| PIR | C71339 | C71339. | |
| HSSP | Q56215 | 1EWR | |
| GenomeReviews | AE000520_GR | TP0328.1 | |
| TIGR | TP0328 | -. | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX MEDLINE=98332770; PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M.,
RA Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D.,
RA Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M.,
RA Weidman J.F., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis
RT spirochete.";
RL Science 281:375-388(1998).
Feature:
CHAIN 1 900 DNA mismatch repair protein mutS.
/FTId=PRO_0000115163.
NP_BIND 626 633 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 900
MRSLASDTPL MRQYHAIRAQ HPDAVLFFRL GDFYEMFDSD ALHVSTLLGL TLTKRNGTPM
CGVPVHTART HIARLLKHGK KVALCEQVSH PVPGELTQRK VIEIISPGTA VEDDFLSQGF
SQYLATVCAS DATVAFSYLE VSTGAFFITS FPRAEAADAL QKEFGRVQPS EVLLSASVLR
SLPELAAILS LYPRLVRTTG ADALFNPEHT KNRLHHCFRT RNLDCLTLLP HSPDLAAAGA
LIAYLEETTR HPLSHVSAIT RYHIHDFVEI DDATRKNLEI LQNLHDSTHA HSLFETLNYT
HTAMGTRLLR YWLHHPLRSQ EEIQKRLSAV VFFHHRPHIL KTLRATLSCV RDVERLVARV
ALEKAHGRDL LALKESLRAI LTFRSLERES PFPPDLLPSE GDTPVLQELY GLLEQSIKED
CPVTLSDGNL IKRGFSASLD ELHRVRDNAN EILKQYLAEE RERTGIGTLK MKYNRMLGHF
LEVSKGHLSA VPAHFIRRRS LSNADRFTTE QLSELEAKLA RAREGLVSFE QELFADIRRT
VCSHTQLLRT NAARVAQLDV LQSFAHAALQ HGWSQPVFIK DGALRITGGR HPVVELHLPS
GEFVPNDLTL SSSEHAVLPR FALITGPNMA GKSTFLRQTA LICLIAQVGS FVPAEKAELT
PVDRIFCRVG AADNLARGES TFLVEMSETA HILRAATRDS LVIMDEVGRG TATEDGLSIA
QAVSEYLLHH VRAKTLFATH YHELSRLAHP QLEHLKLDVL ETDNTIVFLK KVTPGSCGSS
YGIYVARLAG LPESVLARAC ELLKQLQQRA GSAPRASAAH EADAVAQTEA VHAHKAASKP
CAQRVSADLF TQEELIGAEI ASLNPDAITP LEALTLIARW KRSLRGSATQ QSSAMTKRKG