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Description:
DNA repair protein radA homolog (DNA repair protein sms homolog).
Molecular weight: 49305
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
07-MAR-2006, entry version 40.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Treponema.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RADA_TREPA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000520 | AAC65973.1 | - |
| PIR | A71251 | A71251. | |
| GenomeReviews | AE000520_GR | TP1022.1 | |
| TIGR | TP1022 | -. | |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR001984 | Peptidase_S16. | |
| InterPro | IPR004504 | RadA. | |
| PRINTS | PR01874 | DNAREPAIRADA. | |
| PRINTS | PR00830 | ENDOLAPTASE. | |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00416 | sms | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Metal-binding; Nucleotide-binding; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX MEDLINE=98332770; PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M.,
RA Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D.,
RA Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M.,
RA Weidman J.F., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis
RT spirochete.";
RL Science 281:375-388(1998).
Feature:
CHAIN 1 455 DNA repair protein radA homolog.
/FTId=PRO_0000187943.
ZN_FING 11 28 C4-type (Potential).
NP_BIND 97 104 ATP (Potential).
Comments:
-!- FUNCTION: May play a role in the repair of endogenous alkylation
damage (By similarity).
-!- SIMILARITY: Belongs to the recA family. RadA subfamily.
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Sequence length: 455
MAKKTERAFS CVGCGYVHPK WLGRCPECGE WNSFEETPSL SSGDVRAVKK ASSSPVQAFP
LCAVRAQDAQ RISCGIAEFD RVLGGGAVRR SAIMIGGEPG IGKSTLLLQI AAACGKSVLY
VSGEESPGQI RGRADRLNIP IQNIELLCAT RVEDVERVLN TRCPTFVIVD SIQTVFSPEA
GAIPMTINQL KYCANELIAW VKERDSVLFF TAHVTKDGNI AGPKVVEHMV DTVISFERNE
EDIRFLRALK NRFGSVDELG IFTMGENGLS AVQDTAGFFI STRQGMFPVG SATVPVCEGS
RVFMVEIQAL TVPAKSSVTR VFSDRIDSAR VSRVAAVIEK RVGLKFSDQD IYVNVAGGIR
LYEPAVDVAL AMALYSARQN TPVKTNAAFI GEVSLSGEIR PVRRLKTRLK TAYGLGFSTI
YVPIGVEHDT PPPYTLRVVG TLAQTIAEIF SKAKA