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Description:
DNA replication and repair protein recF.
Molecular weight: 41216
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
04-MAY-2001, sequence version 2.
07-MAR-2006, entry version 33.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Treponema.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECF_TREPA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000520 | AAC65001.1 | ALT_INIT |
| GenomeReviews | AE000520_GR | TP0003.1 | |
| TIGR | TP0003 | -. | |
| HAMAP | MF_00365 | - | 1. |
| InterPro | IPR001238 | RecF. | |
| InterPro | IPR003395 | SMC_N. | |
| Pfam | PF02463 | SMC_N | 1. |
| TIGRFAMs | TIGR00611 | recf | 1. |
| PROSITE | PS00617 | RECF_1 | 1. |
| PROSITE | PS00618 | RECF_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA replication; DNA-binding; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX MEDLINE=98332770; PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M.,
RA Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D.,
RA Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M.,
RA Weidman J.F., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis
RT spirochete.";
RL Science 281:375-388(1998).
Feature:
CHAIN 1 352 DNA replication and repair protein recF.
/FTId=PRO_0000196482.
NP_BIND 25 32 ATP (Potential).
Comments:
-!- FUNCTION: The recF protein is involved in DNA metabolism; it is
required for DNA replication and normal SOS inducibility. RecF
binds preferentially to single-stranded, linear DNA. It also seems
to bind ATP (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
-!- SIMILARITY: Belongs to the recF family.
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Sequence length: 352
MTAINFRNLA HHTIDISSPE VFFVGNNGQG KTNILEVLYL AAYGNSFRTR TESELYATHA
RSNEYRVKVM YRGEYTHTVQ IFSKNGKKRI EKNLKKIRTK KELISSIPCI LFFHNDLDFV
VGTPERRRFF LDQSLSMCNP LYLEYLQKYH ALTKTKNREI KEKRVQLLDA LDTQIATVGF
DLVQWRTQLV RDFNVIFTKY YERLGDLAQV RIEYKPSWSD SSVEEIVHSL YKRRKHDLAM
GMSMSGPHRD KIHFTRSQAL FIPQASTGQR RLVSLVLRMS QAVFYTGVTG KLPVLLMDDV
LLELDPEKRE RFMMSLPPYD QLFCTFLPGE AYRRYGREKT RVYFVSEGAC HE