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Description:
ATP-dependent DNA helicase recG (EC 3.6.1.-).
Molecular weight: 77197
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
07-MAR-2006, entry version 39.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Treponema.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECG_TREPA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U70661 | AAB38707.1 | - |
| EMBL | AE000520 | AAC65656.1 | - |
| PIR | D71292 | D71292. | |
| HSSP | Q9WY48 | 1GM5 | |
| GenomeReviews | AE000520_GR | TP0687.1 | |
| TIGR | TP0687 | -. | |
| InterPro | IPR001410 | DEAD. | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR004609 | RecG. | |
| Pfam | PF00270 | DEAD | 1. |
| Pfam | PF00271 | Helicase_C | 1. |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00643 | recG | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Nichols;
RA Stamm L.V., Barnes N.Y.;
RL Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX MEDLINE=98332770; PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M.,
RA Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D.,
RA Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M.,
RA Weidman J.F., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis
RT spirochete.";
RL Science 281:375-388(1998).
Feature:
CHAIN 1 686 ATP-dependent DNA helicase recG.
/FTId=PRO_0000102161.
NP_BIND 298 305 ATP (Potential).
MOTIF 399 402 DEQH box.
Comments:
-!- FUNCTION: Critical role in recombination and DNA repair. Help
process Holliday junction intermediates to mature products by
catalyzing branch migration. Has a DNA unwinding activity
characteristic of a DNA helicase with a 3' to 5' polarity. RecG
unwind branched duplex DNA (Y-DNA) (By similarity).
-!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
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Sequence length: 686
MLIGEIKEPV SVLKGTGKVV LAQLERLNIS TIGDILSYWP RLWEDRTQEQ MFSQWTLAHR
LQVRVSVTAH CWFGFGKSKT LKLVVQDGQG CVAELLCFRR NFLHFMFPVG SEAVVYGSFY
EKDGLLESSS FDIEKIDCIE KKILPVYPLT KGLKQMKLRM LICAAMDQWI GTVDSELPKP
ILEKYHLLTK RDVLLSMHTP RTLDDVAKGK HSLIFEEFFS LQMTIGMRSL QKRGRLPLTQ
GESDQQSAIP SVVSELSLLQ KKLHRCLPFE LTVDQKRVIT EITQDLEREE PMARLIQGDV
GSGKTLVAFF SCLKIIEQGG QVALLAPTEL LARQHADTAA RLLAPIGIRL AFLTGNVKSE
GRAYLLEALV AGEINLVVGT HALFSKSVRY HDLRLVIIDE QHRFGVLQRS ALIQKGREGN
PQGKTPHIIM MSATPIPRTL ALSVFGDLDI SIIKSMPGGR KPVITYIARK TKAEKVYEFV
GNEIEKGRQA YFIYPRIHDI GLTDLKSVQC MYMYLKNYFA RYAVAMIHSK MTEEEQQRIM
KYFSEGTVHI LVATSVVEVG VDVPNANCIV IEHAERFGLS ALHQLRGRVG RGDVQSYCFL
MHGDEMTECA KRRLKIMGST ADGFVIAEED LKLRGPGDVG DTKNFEQSGY SGFRVADPVR
DYPILQVARE AAFELLRKEK GSSEAR