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Description:
Holliday junction ATP-dependent DNA helicase ruvB (EC 3.6.1.-).
Molecular weight: 38665
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
15-DEC-1998, sequence version 2.
07-MAR-2006, entry version 44.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Treponema.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVB_TREPA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000520 | AAC65150.1 | - |
| EMBL | U55214 | AAC45724.1 | - |
| PIR | H71359 | H71359. | |
| HSSP | Q56214 | 1IXS | |
| GenomeReviews | AE000520_GR | TP0162.1 | |
| TIGR | TP0162 | -. | |
| HAMAP | MF_00016 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003959 | AAA_ATPase_centr. | |
| InterPro | IPR004605 | RuvB. | |
| InterPro | IPR008823 | RuvB_C. | |
| InterPro | IPR008824 | RuvB_N. | |
| InterPro | IPR011991 | Wing_hlx_DNA_bd. | |
| Pfam | PF00004 | AAA | 1. |
| Pfam | PF05491 | RuvB_C | 1. |
| Pfam | PF05496 | RuvB_N | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00635 | ruvB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX MEDLINE=98332770; PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M.,
RA Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D.,
RA Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M.,
RA Weidman J.F., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis
RT spirochete.";
RL Science 281:375-388(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-82.
RX MEDLINE=97473495; PubMed=9332349; DOI=10.1016/S0378-1119(97)00234-5;
RA Hardham J.M., Stamm L.V., Porcella S.F., Frye J.G., Barnes N.Y.,
RA Howell J.K., Mueller S.L., Radolf J.D., Weinstock G.M., Norris S.J.;
RT "Identification and transcriptional analysis of a Treponema pallidum
RT operon encoding a putative ABC transport system, an iron-activated
RT repressor protein homolog, and a glycolytic pathway enzyme homolog.";
RL Gene 197:47-64(1997).
Feature:
CHAIN 1 350 Holliday junction ATP-dependent DNA
helicase ruvB.
/FTId=PRO_0000165623.
NP_BIND 63 70 ATP (Potential).
CONFLICT 67 67 L -> V (in Ref. 2).
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing (By similarity).
-!- SUBUNIT: Forms a complex with ruvA (By similarity).
-!- SIMILARITY: Belongs to the ruvB family.
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Sequence length: 350
MDHTASLSPV RPEAQPTDDR ERALRPRLLK DFLGQEKTKR NLRLFIQAAR DRNESLDHLF
LIGPPGLGKT TLAHITACEL GVECKVTGAP ALDKPKDLAG ILTALSERSV FFVDEIHRLK
PAIEEMLYIA MEDYELDWVI GQGPSARTVR IPLPPFTLIG ATTRAGMVSS PLISRFGIVE
RFEFYTPEEL AAIVQRSARL LDITLDARAA LALARCSRGT PRVANRLLRR IRDFAQVAGS
AHISETIVRA GLAHLKIDEL GLELHDIQLL RVMIEHFGGG PVGAETLAIS LGESPETLED
YYEPYLIQIG LMQRTPRGRM ATARAYAHLG LPVPEARTLT PHSPEQGTLL