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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10601
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
07-MAR-2006, entry version 43.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Treponema.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_TREPA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000520 | AAC65502.1 | - |
| PIR | A71315 | A71315. | |
| GenomeReviews | AE000520_GR | TP0514.1 | |
| TIGR | TP0514 | -. | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 2. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX MEDLINE=98332770; PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M.,
RA Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D.,
RA Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M.,
RA Weidman J.F., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis
RT spirochete.";
RL Science 281:375-388(1998).
Feature:
CHAIN 1 960 UvrABC system protein A.
/FTId=PRO_0000093109.
DOMAIN 331 605 ABC transporter 1.
DOMAIN 616 953 ABC transporter 2.
NP_BIND 35 42 ATP (Potential).
ZN_FING 270 297 C4-type.
NP_BIND 657 664 ATP (Potential).
ZN_FING 756 782 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 960
MGSAARNLCI KGAREHNLKN IDVMLPRDAL VVISGLSGSG KSSLAFDTIF AEGQRRYVES
LSAYARQFLG RLDKPDVDSI EGLSPAIAIE QKTTQRNPRS TVGTVTEIYD YYRLLFARIG
RAHCPHCARE IKEQTVDQIV DTLMTVPSGS RIQLLAPVVR GKKGTHHKVL EAARKDGFVR
ARIDGALLHL HERISLDKQK KHSIDIVVDR IQLSDTVRKR LTESVETTLG YADGLLTVLV
QGENSGTVSG KIETSALLPS ELFFSQKNAC AHCNVSVPEL QPRLFSFNAP FGACPSCAGL
GIMQTFDLDR IVPDQNRSFN EGAFLPFKPE HEWNRVRFAA LAEKYHFSLD DPVRNLSKHA
LDIILHGSGS EALEFSHERK DGSRTARYIK PWPGIFSELH RRYAESCTHS QREVYERYLS
VRTCEACRGM RLKPESLAVT IEKKNIHALS ALSVDDSCEF FKTLHLTEVE ATIAQQILKE
ITDRLEFLQN VGLGYLTLER AAATLSGGEA QRIRLATQIG SRLTGVLYIL DEPSIGLHQR
DNERLIQTLL HLRDLGNTVL VVEHDEQTLR VADYIVDLGP GAGVHGGYVV AAGSPPEVMQ
VQASLTGQYL AGAITLPIPA VRRTGNGNVL TVHDVHEHNL QHISVRIRLG TFTCITGVSG
SGKSTLLIDV LYPALYNRVM NGRLPEGKFS SIEGTEHLDK VIYVDQSPIG RTPRSNPATY
VGVFTDIRML FSQVPEAKMR GYKPGRFSFN VPGGRCEHCK GDGVITIEMN FLPDVYITCD
VCHGTRFNRE TLAVFYKGKN ISHVLDMTIE EARSFFSAVP PIVRKLEALC SVGLGYVRLG
QSALTLSGGE AQRVKLALEL SKRATGKTLY IFDEPTTGLH FADIIQLMEV VQRLVDQGNT
VVMIEHNMDV IVQADCVIDL GPEGGMHGGT IVAQGSPEAV SQITESRTGW YIKEVLCKKT