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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 78210
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
07-MAR-2006, entry version 36.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Spirochaetaceae Treponema.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_TREPA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000520 | AAC65452.1 | - |
| PIR | B71322 | B71322. | |
| GenomeReviews | AE000520_GR | TP0472.1 | |
| TIGR | TP0472 | -. | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX MEDLINE=98332770; PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M.,
RA Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D.,
RA Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M.,
RA Weidman J.F., Smith H.O., Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis
RT spirochete.";
RL Science 281:375-388(1998).
Feature:
CHAIN 1 691 UvrABC system protein C.
/FTId=PRO_0000138356.
DOMAIN 204 239 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 691
MRPSESLVET LRIQALSAPS TSGVYLWKDV HGVVIYVGKA KSLRTRLTSY FRCRHDPKTR
VLMSRAAALE YLQTQHEYEA LLLENTLIKK HTPRYNICLK DGKTYPLLKL TCEPFPRIFR
TRQFCQDGAR YFGPFPDVQI LDSFLKLILR TYKIRTCTTL RKRKNPCLYY HLKRCDAPCC
GWVSPRTYQK DIHEITLLLE GNIDATVARL EKRMKRAVRQ EAFEAAARIR DDIQAIRCIT
HKSLVQDMDE RARDYIAWSS TGAIVTFAVL RMRGGKLNGR ELFRTRSLKN EEEILSEFLI
TYYSDHTIPP HLFVHSSAGL AEHWLSHKAG TQCTVTLIPL HTFPTPQTPS STVTTNAPTL
AASQNSNAVQ DSGLRSCSET STMHTLQKAH DACTASEGTR ENTPHESAHT PHHRAILAMA
QLNAHEDITR YLKNRGADDA LKELQKQLHL ARIPTLIEGF DISHLGGKYT VASLICFKNG
APDTKNYRLF NLRAHDTRID DFASMREAIA RRYTHTPEGY TLPDLILVDG GIGHVSAAQH
VLDALGLSIP LVGLAKRAEE LFIPNSPTPL VLDRRNPALH MLQRIRDEAH RFAITRNRHL
RTKKELVLSF ERLPHVGKVR AHRLLAHFGS FRSLQSATPQ DIATAIHIPL TQAHTILHAA
TRSTTAPVRE EYKEHEHDPQ GESPGPGRKT D