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Description:
DNA mismatch repair protein mutL.
Molecular weight: 67795
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 21.
Phylogenetic order:
Bacteria Firmicutes Bacillales Listeriaceae Listeria.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_LISMO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL591979 | CAC99482.1 | - |
| PIR | AD1250 | AD1250. | |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AL591824_GR | lmo1404.1 | |
| ListiList | LMO01404 | -.1 | |
| BioCyc | LMON169963:LMO1404-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EGD-e / Serovar 1/2a;
RX MEDLINE=21537279; PubMed=11679669; DOI=10.1126/science.1063447;
RA Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A.,
RA Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T.,
RA Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P.,
RA Domann E., Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O.,
RA Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P.,
RA Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D.,
RA Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G.,
RA Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H.,
RA Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R.,
RA Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A.,
RA Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT "Comparative genomics of Listeria species.";
RL Science 294:849-852(2001).
Feature:
CHAIN 1 601 DNA mismatch repair protein mutL.
/FTId=PRO_0000177954.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 601
MAKHIVELTD ALSNKIAAGE VVERPASVVK ELVENAIDAG STVIDILVEE AGLNKITIID
NGSGIEEEDV ATAFLRHATS KIKNEADLFR VHTLGFRGEA LPSIASVSHL AMETSTGETK
GTSISLEGGK IIEQKSGHAR KGTQIEVSQL FFNTPARLKY LKSLPTELGN ITDILNRLAL
AHPDISFRFS HNGKPLLQTN GNGDLRQVIA AIYGISIAKK SIPVKAESLD FKISGYAVLP
EVNRSNRNYI STIINGRFIK NFALVKAIQE GYHTLLPIGR FPIIVLQIEM DPIIVDVNVH
PAKLEVRLSK EKELGQLISQ MIKEAFHKLQ LIPEGEISKK QKEVQKSEQI QMSFEENKPA
KEIPTLFSKP TIPEYVPSDE DAPREDDFIL ETMPPYEPQA EQEEHSKERI PKMYPIGQMH
ATYIFAQNEN GLYIIDQHAA QERIKYEFYR EKIGEVSREL QELLVPIVLE FPADEYVRLE
EQKAKLEEVG VFLENFGQNS FIIRAHPTWF PKDQEEEMLR EIIDEALSAP SISIHKLRED
TAIMMSCKKS IKANHYLTTQ DMEALLDTLR EASDPFTCPH GRPVIIQYST YELEKMFKRV
M