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Description:
DNA mismatch repair protein mutL.
Molecular weight: 68208
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
07-MAR-2006, entry version 21.
Phylogenetic order:
Bacteria Firmicutes Bacillales Listeriaceae Listeria.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_LISIN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL596168 | CAC96672.1 | - |
| PIR | AH1612 | AH1612. | |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AL592022_GR | lin1441.1 | |
| ListiList | LIN01441 | -.1 | |
| BioCyc | LINN1642:LIN1441-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIP 11262 / Serovar 6a;
RX MEDLINE=21537279; PubMed=11679669; DOI=10.1126/science.1063447;
RA Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A.,
RA Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T.,
RA Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P.,
RA Domann E., Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O.,
RA Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P.,
RA Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D.,
RA Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G.,
RA Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H.,
RA Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R.,
RA Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A.,
RA Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT "Comparative genomics of Listeria species.";
RL Science 294:849-852(2001).
Feature:
CHAIN 1 603 DNA mismatch repair protein mutL.
/FTId=PRO_0000177952.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 603
MAKHIVELTD ALSNKIAAGE VVERPASVVK ELVENAIDAG STVIDILVEE AGLNKITIID
NGSGIEEEDV AIAFLRHATS KIKNEADLFR VHTLGFRGEA LPSIASVSHL TLETSTGETK
GTTISLEGGK IIEQKSGHAR KGTQIEVSQL FFNTPARLKY LKSLPTELGN ITDILNRLAL
AHPDISFRFS HNGKPLLQTN GNGDLRQVIA AIYGVSIARK SIPVKAESLD FKISGYAVLP
EVNRSNRNYI STIINGRFIK NFALVKAIQE GYHTLLPIGR FPIIVLQIEM DPIIVDVNVH
PAKLEVRLSK EKELGQLISQ MIKDAFHQLQ LIPDGEVSKK QKEQQKSEQI QMSFEENRQP
KEPPTLFSKP NIPEYVPSDE IVPKEDDFIL ETMPTYNPET QPEQVEEQKE RIPKMYPIGQ
MHATYIFAQN ENGLYIIDQH AAQERIKYEF YREKIGEVSR ELQELLVPIV LEFPSDEYVR
LEEQKAKLEE VGVFLENFGQ NSFIIRAHPT WFPKDQEEEM LREIIDEALS APSISIHKLR
EDTAIMMSCK KSIKANHYLT MQDMEALLDT LREASDPFTC PHGRPVIIQY STYELEKMFK
RVM