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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10650
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
07-MAR-2006, entry version 25.
Phylogenetic order:
Bacteria Firmicutes Bacillales Listeriaceae Listeria.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_LISIN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL596173 | CAC97858.1 | - |
| PIR | AB1761 | AB1761. | |
| GenomeReviews | AL592022_GR | lin2631.1 | |
| ListiList | LIN02631 | -.1 | |
| BioCyc | LINN1642:LIN2631-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 2. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIP 11262 / Serovar 6a;
RX MEDLINE=21537279; PubMed=11679669; DOI=10.1126/science.1063447;
RA Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A.,
RA Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T.,
RA Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P.,
RA Domann E., Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O.,
RA Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P.,
RA Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D.,
RA Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G.,
RA Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H.,
RA Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R.,
RA Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A.,
RA Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT "Comparative genomics of Listeria species.";
RL Science 294:849-852(2001).
Feature:
CHAIN 1 956 UvrABC system protein A.
/FTId=PRO_0000093060.
DOMAIN 325 593 ABC transporter 1.
DOMAIN 605 936 ABC transporter 2.
NP_BIND 33 40 ATP (Potential).
ZN_FING 252 279 C4-type.
NP_BIND 639 646 ATP (Potential).
ZN_FING 738 764 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 956
MDKEKIVIQG ARAHNLKNID VEIPRDKLVV MTGLSGSGKS SLAFDTIYAE GQRRYVESLS
AYARQFLGQM DKPDVDLIEG LSPAISIDQK TTSRNPRSTV GTVTEIHDYL RLLYARVGHP
VCPNHGIEIT SQTIEQMVDR VLEYPEKTRI QIMAPIVSGK KGTHKKTIEE IKKEGYVRIR
VDGEIYDIND EIEIEKNKKH SIEIIIDRIV IKEGINTRLY DSIEAALRLA DGYAVVEIMG
DKELLFSEHY ACPYCGFSVG ELEPRMFSFN SPFGACPTCD GLGTKLEVDV DTVIPDRSLT
LNEGAIVPWR PISSQYYPQM LASACKEFGI DMDTPIEELS KEALDIVLNG SKDKEFYFEY
KNDFGMTRET WIPFEGILPN IERRYRETNS DFTRDQMAQY MTDLPCPSCK GYRLKEETLS
VKVNNHHIGQ ISEFSINEAL DFFDSLELSE KETQIAAPIF KEVRARLGFL KNVGLDYLTM
SRAAGTLSGG EAQRIRLATQ IGSRLTGVLY ILDEPSIGLH QRDNDRLINT LQSMRDIGNT
LIVVEHDEDT MMAADYLIDI GPGAGEHGGR IVAAGTPEEV AKNKNSITGD YLSGKKFIPV
PAKRRKGNGL ELEIVGAKAN NLKNVNAKIP LATFSCVTGV SGSGKSSLVN EVLRKALARK
LNRNHAKPGE HKEIKGIENL EKIINIDQSP IGRTPRSNPA TYTGAFDDIR DLFASTNEAK
VRGYKKGRFS FNVKGGRCEA CKGDGIIKIE MHFLPDVYVP CEVCHGKRYN GETLDIRYKG
KNIAEVLEMT VEEGLEYFTN QPRIARKLQT IVDVGLGYIR LGQPATTLSG GEAQRVKLAS
ELHKRSNGKS FYILDEPTTG LHADDIGRLL KVLQRLVEEN GDTVLVIEHN LDVIKQADYL
IDLGPEGGDG GGQIIATGTP EKIARSKKSY TGKYLKPILE RDKERTEERI ATAKKK