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Description:
DNA mismatch repair protein mutL.
Molecular weight: 67640
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
15-FEB-2005, sequence version 2.
07-MAR-2006, entry version 18.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Leptospiraceae Leptospira.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_LEPIN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE011300 | AAN48374.1 | ALT_INIT |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE010300_GR | LA1175.1 | |
| BioCyc | LINT189518:LA1175-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=56601 / Serogroup Icterohaemorrhagiae / Serovar lai;
RX MEDLINE=22598143; PubMed=12712204; DOI=10.1038/nature01597;
RA Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H.,
RA Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F.,
RA Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F.,
RA Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W.,
RA Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A.,
RA Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z.,
RA Xu J.-G., Zhao G.-P.;
RT "Unique physiological and pathogenic features of Leptospira
RT interrogans revealed by whole-genome sequencing.";
RL Nature 422:888-893(2003).
Feature:
CHAIN 1 593 DNA mismatch repair protein mutL.
/FTId=PRO_0000177951.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 593
MGKIQELSPE LINQIAAGEV IESAHSVVKE LMENSMDASA TQVDVESKDG GLSLLRITDN
GTGIEPEDLE PALKRHATSK IQDYKDLESV LSYGFRGEAL ASIASVSRLT LESGTKEQKT
AWKTRSVAGK ISEKEEIPGF IGTKILVEEL FFNTPVRRKF LKSIRSEDKK IRDRVTTQAL
AREDVRFRLF QDGKEVFVLP TRENKKERII DLFGENFRDH LLEVSLERGG IQATGYISDP
DFYKSNRTGQ FIFINGRPIE IKYSSVLLKK AYDELLPPNG HPYCFLFFEI DPSRVDVNVH
PAKREIRFLD EDGFNGFFLA LIQKELRSST PVSFLELKKR LLKPAPETHS TTSFYQARSS
GKNPLLGREL FSGVSKQEGF ELDRMGPGVS LSELTDERVK HSSFVPKKHF GVLFETFILA
EAEDGFYIID QHTAHERIRY EEVLRKLEKR NYGIQPLLTP IRIDVSKQEQ EDILNRKKEY
EEVGIFLDPL GEDSIVLREI PAYMEPGQEK EIVLDFLNRT EGKETSEPEL YDLMAKCVAC
RSAIKKGDQL SDPILAEILN RLSYCENPSR CPHGRPTLVK LSRDDLERMF HRK