|
|
|
|
|
|
Description:
DNA mismatch repair protein mutS.
Molecular weight: 97182
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
07-MAR-2006, entry version 19.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Leptospiraceae Leptospira.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_LEPIN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE011385 | AAN49345.1 | - |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | AE010300_GR | LA2146.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=56601 / Serogroup Icterohaemorrhagiae / Serovar lai;
RX MEDLINE=22598143; PubMed=12712204; DOI=10.1038/nature01597;
RA Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H.,
RA Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F.,
RA Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F.,
RA Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W.,
RA Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A.,
RA Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z.,
RA Xu J.-G., Zhao G.-P.;
RT "Unique physiological and pathogenic features of Leptospira
RT interrogans revealed by whole-genome sequencing.";
RL Nature 422:888-893(2003).
Feature:
CHAIN 1 848 DNA mismatch repair protein mutS.
/FTId=PRO_0000115107.
NP_BIND 605 612 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 848
MNLESTATSA EYWSDLADAL NTPMMKQFLA IKKDFPDTIL FFRMGDFYEM FLEDAKIASS
ILDIALTKRQ NAVPMCGIPY HSKDNYISRL LNAGKKIAIC EQSKPEEAGS KLMTRDVVRI
ITPGTVIEEN LLSGFQNNYL AVLHLKKSLI YFAIADFSTG EVFYSSVSVT GLERLIAELE
KFKPSEICVP KSEHTFFQEL EYFKNREFTV LKNQIETSEK DSFQVLSKYL NEYIRETYRD
NKLVLREPKI LSSGKFLEMD RETIRNLELV ENEKEKNNTL YSIFNFCNTA KGKRLLKQRI
LFPECDPVVL YSRWEKQDIL LKTVLAPYIT ALKDFGDLER ILTRFRGNHA YPRDFRSLLN
SISSGIKLKE ELEKVSYPFL IPIEELKKIS DFIQERLHPG DDLPVILGNG IFLKKGFSQK
LDQAREAGVK GKDWILDLET KEKKRTGLNT LKIRYNKIVG YFIEISRAQA EQAPKDYLKK
QTLVGSERFT MPKLEEIERT ILEADEIIQE IERTEFNRMV EEVLKFSSSL LSFSEEIGDL
DFQISLLTAK DKFGWIRPKL SEDRSLDLSD SRHPVVEATL PPGQEFIPNS VYLDTQDKAI
AVLTGPNMAG KSTFMRQIAL NQILFQIGAF VPAKSAKLPI VDKLFTRIGA GDNLTAGEST
FFVEMKETAN ILNHYTEDSL ILFDEVGRGT STYDGMSIAW SILEYLSSLS VRPKTIFATH
YHELTELSRL GGIFNLYLET LEKEDRVLFL RKVKVGKAKK SFGIYVAKIA GVPEPIVKRA
AELLTDLESK KKEIKIQEAQ PTLFTEPETK NFNSQTEESI LKLKLEEMTP IEALKTLEDF
QKKLRKQK