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Description:
Protein recA (Recombinase A).
Molecular weight: 39687
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
06-DEC-2002, sequence version 2.
07-MAR-2006, entry version 42.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Leptospiraceae Leptospira.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECA_LEPIN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U29169 | AAA98505.1 | - |
| EMBL | AE011389 | AAN49378.1 | - |
| HSSP | Q59560 | 1UBC | |
| GenomeReviews | AE010300_GR | LA2179.1 | |
| BioCyc | LINT189518:LA2179-MONOMER | -.1 | |
| HAMAP | MF_00268 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR001553 | RecA_bac. | |
| Pfam | PF00154 | RecA | 1. |
| PRINTS | PR00142 | RECA. | |
| ProDom | PD000229 | RecA | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR02012 | tigrfam_recA | 1. |
| PROSITE | PS00321 | RECA_1 | FALSE_NEG. |
| PROSITE | PS50162 | RECA_2 | 1. |
| PROSITE | PS50163 | RECA_3 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Kenniwicki / Serogroup Pomona / Serovar pomona;
RA Yelton D.B., Salvitti J.A.;
RL Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=56601 / Serogroup Icterohaemorrhagiae / Serovar lai;
RX MEDLINE=22598143; PubMed=12712204; DOI=10.1038/nature01597;
RA Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H.,
RA Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F.,
RA Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F.,
RA Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W.,
RA Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A.,
RA Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z.,
RA Xu J.-G., Zhao G.-P.;
RT "Unique physiological and pathogenic features of Leptospira
RT interrogans revealed by whole-genome sequencing.";
RL Nature 422:888-893(2003).
Feature:
CHAIN 1 366 Protein recA.
/FTId=PRO_0000122744.
NP_BIND 81 88 ATP (By similarity).
CONFLICT 110 110 A -> G (in Ref. 1).
CONFLICT 246 260 IKEKEESVGNRVRVK -> TTEKDRICRNRDESN (in
Ref. 1).
CONFLICT 266 267 CA -> SCP (in Ref. 1).
CONFLICT 272 272 Q -> P (in Ref. 1).
CONFLICT 280 280 N -> NH (in Ref. 1).
CONFLICT 318 318 E -> AS (in Ref. 1).
CONFLICT 327 331 NPEIA -> KTLKLT (in Ref. 1).
CONFLICT 345 366 PLLVQENNKKSRKEEKLEQAAG -> TFVSSGK (in
Ref. 1).
Comments:
-!- FUNCTION: Can catalyze the hydrolysis of ATP in the presence of
single-stranded DNA, the ATP-dependent uptake of single-stranded
DNA by duplex DNA, and the ATP-dependent hybridization of
homologous single-stranded DNAs. It interacts with lexA causing
its activation and leading to its autocatalytic cleavage.
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the recA family.
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Sequence length: 366
MGESIMKKAK EDAPSVDDSK KLAIEQAMSQ IEKQFGKGSI MKLGSDSAKQ TVQVIPSGSL
DLDIALGIGG YPIGRIVEIY GPESSGKTTL TLSAIAEAQK RGGVAAFIDA EHALDPSYAK
KLGVNIDELL VSQPDNGEEA LEICESLVRS NAIDLIVIDS VAALVPKAEI EGDMGDSHMG
LQARLMSQAL RKLTGTIAKS KTVVIFINQI RMKIGVMFGS PETTTGGNAL KFYCSVRLDI
RKIETIKEKE ESVGNRVRVK VVKNKCAPPF KQAEFDIIFN AGISREGSLV DLGVKHDIIH
KAGAWYSYNT EKIGQGKEAA KEYLKNNPEI ALTIENMVRD LNSLPLLVQE NNKKSRKEEK
LEQAAG