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Description:
DNA replication and repair protein recF.
Molecular weight: 42310
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
07-MAR-2006, entry version 15.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Leptospiraceae Leptospira.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECF_LEPIN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF434658 | AAN64013.1 | - |
| EMBL | AE011192 | AAN47202.1 | - |
| GenomeReviews | AE010300_GR | LA0003.1 | |
| BioCyc | LINT189518:LA0003-MONOMER | -.1 | |
| HAMAP | MF_00365 | - | 1. |
| InterPro | IPR001238 | RecF. | |
| InterPro | IPR003395 | SMC_N. | |
| Pfam | PF02463 | SMC_N | 1. |
| TIGRFAMs | TIGR00611 | recf | 1. |
| PROSITE | PS00617 | RECF_1 | 1. |
| PROSITE | PS00618 | RECF_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA replication; DNA-binding; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Serogroup Pomona;
RX MEDLINE=22286320; PubMed=12399032;
RA Zuerner R.L., Huang W.M.;
RT "Analysis of a Leptospira interrogans locus containing DNA replication
RT genes and a new IS, IS1502.";
RL FEMS Microbiol. Lett. 215:175-182(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=56601 / Serogroup Icterohaemorrhagiae / Serovar lai;
RX MEDLINE=22598143; PubMed=12712204; DOI=10.1038/nature01597;
RA Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H.,
RA Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F.,
RA Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F.,
RA Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W.,
RA Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A.,
RA Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z.,
RA Xu J.-G., Zhao G.-P.;
RT "Unique physiological and pathogenic features of Leptospira
RT interrogans revealed by whole-genome sequencing.";
RL Nature 422:888-893(2003).
Feature:
CHAIN 1 365 DNA replication and repair protein recF.
/FTId=PRO_0000196427.
NP_BIND 30 37 ATP (Potential).
CONFLICT 207 207 R -> K (in Ref. 1).
CONFLICT 240 240 H -> R (in Ref. 1).
CONFLICT 264 264 S -> T (in Ref. 1).
CONFLICT 363 363 S -> P (in Ref. 1).
Comments:
-!- FUNCTION: The recF protein is involved in DNA metabolism; it is
required for DNA replication and normal SOS inducibility. RecF
binds preferentially to single-stranded, linear DNA. It also seems
to bind ATP (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the recF family.
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Sequence length: 365
MFLKHLTIQN FRNHEELSLD FDSRLIFFVG DNGEGKTNLL EAICILSWLK SFRESEDSNL
IRWGSENYFL RGKIKDNLKE SVLEIGFTSK PSVKRKLKFN QEEIKKRTDL IGKFITVLLT
PMDLKIIEGG PAERRKFIDA FISSFDPFYL ESLLEYNKIL KHRNALLKSG NPDISHLSIW
DKKIVEKGIF ILNKRREVVL ELNSFYRVNL DKLSGGKDGL ELIYKPNVKD QDEFLEKLNH
NLSRDLRLGY TSVGIHRDDL FIGSDQRDIT EFGSQGQKRS TVIALKAATF NYYKNILNTI
PVLLIDDVIR ELDVKRREYF VDLVVTAGQA FFTTTDLEGI QDYVGKLKDQ KQIFLIRQGK
VESIK