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Description:
Holliday junction ATP-dependent DNA helicase ruvB (EC 3.6.1.-).
Molecular weight: 38035
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
07-MAR-2006, entry version 19.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Leptospiraceae Leptospira.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVB_LEPIN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE011267 | AAN48009.1 | - |
| HSSP | Q56313 | 1J7K | |
| GenomeReviews | AE010300_GR | LA0810.1 | |
| HAMAP | MF_00016 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003959 | AAA_ATPase_centr. | |
| InterPro | IPR004605 | RuvB. | |
| InterPro | IPR008823 | RuvB_C. | |
| InterPro | IPR008824 | RuvB_N. | |
| InterPro | IPR011991 | Wing_hlx_DNA_bd. | |
| Pfam | PF00004 | AAA | 1. |
| Pfam | PF05491 | RuvB_C | 1. |
| Pfam | PF05496 | RuvB_N | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00635 | ruvB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=56601 / Serogroup Icterohaemorrhagiae / Serovar lai;
RX MEDLINE=22598143; PubMed=12712204; DOI=10.1038/nature01597;
RA Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H.,
RA Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F.,
RA Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F.,
RA Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W.,
RA Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A.,
RA Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z.,
RA Xu J.-G., Zhao G.-P.;
RT "Unique physiological and pathogenic features of Leptospira
RT interrogans revealed by whole-genome sequencing.";
RL Nature 422:888-893(2003).
Feature:
CHAIN 1 341 Holliday junction ATP-dependent DNA
helicase ruvB.
/FTId=PRO_0000165550.
NP_BIND 58 65 ATP (Potential).
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing (By similarity).
-!- SUBUNIT: Forms a complex with ruvA (By similarity).
-!- SIMILARITY: Belongs to the ruvB family.
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Sequence length: 341
MAKSHTLNPE EEFEEESGLR PSLLSEFIGQ KEVLNNLTVY VQAAKNRKRA LDHVLISGPP
GLGKTTLAGI ISNELGTRLT ITSAPVITKG ADLARLLTSM GENEILFIDE IHTLPKKLEE
ILYPAMENYM IDLVIGEGVT AQMVQIPLKP FTLVGATTRS GLISEPLKSR FGIQLRLDYY
NDEEMKQIVL RSSKILGVLI EDDAALEIGK RSRKTPRIAN HLLKRIRDFS EVEGNLSVKK
NLCLKAFEKM GIDDLGLDGM DRQILDCMID RYKGGPVGLK AIAVVVGEEE KTIEDTYESF
MVRIGLINRT PAGRVATEKA YRQLKRMEDF SVHHGQDPTL F