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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10553
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
07-MAR-2006, entry version 18.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Leptospiraceae Leptospira.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_LEPIN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE011392 | AAN49411.1 | - |
| GenomeReviews | AE010300_GR | LA2212.1 | |
| BioCyc | LINT189518:LA2212-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 2. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=56601 / Serogroup Icterohaemorrhagiae / Serovar lai;
RX MEDLINE=22598143; PubMed=12712204; DOI=10.1038/nature01597;
RA Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H.,
RA Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F.,
RA Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F.,
RA Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W.,
RA Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A.,
RA Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z.,
RA Xu J.-G., Zhao G.-P.;
RT "Unique physiological and pathogenic features of Leptospira
RT interrogans revealed by whole-genome sequencing.";
RL Nature 422:888-893(2003).
Feature:
CHAIN 1 948 UvrABC system protein A.
/FTId=PRO_0000093059.
DOMAIN 274 592 ABC transporter 1.
DOMAIN 603 934 ABC transporter 2.
NP_BIND 31 38 ATP (Potential).
ZN_FING 249 277 C4-type.
NP_BIND 638 645 ATP (Potential).
ZN_FING 737 763 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 948
MQEIRIRGAR EHNLKNINVD IPRDQLVVIT GLSGSGKSSL AFDTIYAEGQ RRYVESLSAY
ARQFLGQMEK PDLDLIEGLS PAISIEQKTT HRNPRSTVGT VTEIYDYLRL LYARVGKPHC
PECGTPIQSM SIDQITARVL AFPQGSKLQI LAPVISGKKG EHKDVLEKIR KDGFNRVRIN
GEIRTLEEEI VLKKNFKTSI EIVVDRIVMK EGIRSRLADS VETALKQSEG LVILDDGSKD
HILSQKMACP NGHDIGFTEL SPRMFSFNSP YGACETCDGL GSLLEFDEDL LVNDPELSLV
DGCIEAWAGS KSNGFWFMAT LKSLSDSLKF KMNTPWKDLP EKTRQTILYG DKKIKIEYDF
RGANSHYEFT KEYEGVIPNL QRRYKETKSD SMRQWFESYM TNHPCPSCKG KRLKRESLSV
KVHNVPVDEF TSYSIEKALN FVQNLKVTGA EEIIAKPILK EIHQRLSFLN DVGVGYLTLE
RSAGSLSGGE AQRIRLATQI GSRLMGVLYI LDEPSIGLHQ RDNTKLVSTL KNLRDLGNTV
LVVEHDQETM EESDWLIDMG PGAGVHGGSI VCAGTPAEVS KHKNSLTGKY LSGRLKVPIP
AKLREGNGSK LQIIGAKENN LKNIDVNIPL GKLVVITGVS GSGKSTLIND ILYNAAAHKV
MKMKTLAGKH KTIKGFENID KIINIDQSPI GRTPRSNPAT YTGLFTPIRE MFAGLEEAKL
RGYGPGRFSF NVSGGRCETC EGDGILKIEM HFLPDVYVTC EVCKGKRYNQ ETLEVRYKGK
NIFDVLEMTV EDANQFFENI PIVKRKLETL LEVGLGYIRL GQPATTFSGG EAQRIKLATE
LSKRPTGKTL YILDEPTTGL HFEDVRRLSE VLHTLVDRGN SMIVIEHNLD VIKQADWIVD
MGPEGGDGGG LVIAEGIPKD IAKIKNSYTG QYLKKIFTSS EKISRKTK