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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 69762
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
07-MAR-2006, entry version 19.
Phylogenetic order:
Bacteria Spirochaetes Spirochaetales Leptospiraceae Leptospira.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_LEPIN:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE011387 | AAN49365.1 | - |
| GenomeReviews | AE010300_GR | LA2166.1 | |
| BioCyc | LINT189518:LA2166-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF00633 | HHH | 2. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| SMART | SM00278 | HhH1 | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=56601 / Serogroup Icterohaemorrhagiae / Serovar lai;
RX MEDLINE=22598143; PubMed=12712204; DOI=10.1038/nature01597;
RA Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H.,
RA Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F.,
RA Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F.,
RA Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W.,
RA Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A.,
RA Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z.,
RA Xu J.-G., Zhao G.-P.;
RT "Unique physiological and pathogenic features of Leptospira
RT interrogans revealed by whole-genome sequencing.";
RL Nature 422:888-893(2003).
Feature:
CHAIN 1 609 UvrABC system protein C.
/FTId=PRO_0000138311.
DOMAIN 208 243 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 609
MPEILNHTLI LEKIKNLGAS PGCYLWKSKK GEVLYVGKAK NLDKRVRSYL KENHPDVKTK
VLQREIFDLD WIATGTEKEA LILEATLIKK HNPRFNVRLK DDKKYPYICV SLSEPYPMVY
VTRKLKDNGD RYFGPYSDVK STRETLDIIL RIFPVRKTRQ VLPLPRPRRP CLNFDMGRCL
GPCQGNIPVE DYKVIIDQVI QFLEGRKESL VSDLNIKMSN ASERLDFEKA ARYRDMLQRI
QNFREKQTVV SLEGGDEDVI GFARKQDEGQ VILLEIRGGR LETKKSFPIQ GVLDAENSEI
LGAFFRDYYL NASLVPPCIF IPADIQDEVI PVIDVLQEKT GFRPKIKFPK GGDKRSLLKI
AEKNAELGLS ERLLATHYRD QTASLKEIQE MFSLERLPHI IECYDISHFQ GSQPVASGVM
FVEGKPFKQG YRKYNIQGYE GINDPGMIHE VISRRLQRII NEEGVFPDLI VIDGGLTQLT
KACEAAVEAG AEGIPMVGLA KKREEIFFPG ENEPFIFDMN SPGMKLLRHL RDEAHRFGVS
HHRSRRNKET MRSLIQEVPD IGFKRSKLLL QHFSGEKKIE EATKEELLLV PGIGENLAEK
ILKQLQKKE