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Description:
DNA mismatch repair protein mutL.
Molecular weight: 65193
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
15-NOV-2002, sequence version 2.
07-MAR-2006, entry version 20.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rhizobiales Rhizobiaceae Agrobacterium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_AGRT5:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE009038 | AAL41715.1 | - |
| EMBL | AE008004 | AAK86509.1 | ALT_INIT |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AE007869_GR | AGR_C_1260.1 | |
| GenomeReviews | AE008688_GR | Atu0699.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=21608550; PubMed=11743193; DOI=10.1126/science.1066804;
RA Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P.,
RA Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L.,
RA Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr.,
RA Chapman P., Clendenning J., Deatherage G., Gillet W., Grant C.,
RA Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A.,
RA Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D.,
RA Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M.,
RA Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M.,
RA Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V.,
RA Nester E.W.;
RT "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT C58.";
RL Science 294:2317-2323(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=21608551; PubMed=11743194; DOI=10.1126/science.1066803;
RA Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M.,
RA Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L.,
RA Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F.,
RA Wollam C., Allinger M., Doughty D., Scott C., Lappas C., Markelz B.,
RA Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G.,
RA Cielo C., Slater S.;
RT "Genome sequence of the plant pathogen and biotechnology agent
RT Agrobacterium tumefaciens C58.";
RL Science 294:2323-2328(2001).
Feature:
CHAIN 1 606 DNA mismatch repair protein mutL.
/FTId=PRO_0000177922.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 606
MAIKQLSETL INQIAAGEVI ERPSSATKEL VENAIDAGAT RIEIATAGGG KGLVRITDNG
SGMSPADLEL AVRRHCTSKI STTLDDIRTL GFRGEALPSI GSVAKLTITS RQQGAEQGSV
ISVTGGKVSD VRPAASNAGT IVEVRDLFFA TPARLKFLKT ERAEAAAITE VVKRMAIAFP
HIRFVLSGTD RSTLEIPSTG DDHLARMAQI LGAEFKDNAI EIDAGREDVT LTGFAGVPTF
NRGNSSHQYV FVNGRPVQDK LLLSAIRGAY AETVPHGRYP VAVLSITLDP AFVDVNVHPA
KSDVRFRDPG LIRGLIVGAI RQALTRDGDR AATTGASQMM NAFRPGYSPS GLRPSPSATW
SAATSPSRPL AVSGDMQFAE AAQSRFSDIT MPTARAEPRE AYEASQSPSP EPVLYPLGAA
RAQLHENYII AQTENGLVIV DQHAAHERLV FEEMRNALHS RRPPSQVLLI PEIIDLPEED
CDRLMDHAAG FDALGLVIER FGPGAIAVRE TPAMLGEVNV QGLVRQLADE IAEWDAASTL
ANKLEYVAAT MACHGSVRSG RRMRPEEMNA LLRQMENTPG SGQCNHGRPT YIELKLSDIE
RLFGRS