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Description:
DNA mismatch repair protein mutS.
Molecular weight: 98204
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-JUN-2002, sequence version 1.
07-MAR-2006, entry version 20.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rhizobiales Rhizobiaceae Agrobacterium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_AGRT5:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE009005 | AAL41367.1 | ALT_INIT |
| EMBL | AE007972 | AAK86162.1 | - |
| PIR | A97401 | A97401. | |
| PIR | AI2618 | AI2618. | |
| HSSP | P23909 | 1NG9 | |
| GenomeReviews | AE007869_GR | AGR_C_602.1 | |
| GenomeReviews | AE008688_GR | Atu0345.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=21608550; PubMed=11743193; DOI=10.1126/science.1066804;
RA Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P.,
RA Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L.,
RA Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr.,
RA Chapman P., Clendenning J., Deatherage G., Gillet W., Grant C.,
RA Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A.,
RA Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D.,
RA Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M.,
RA Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M.,
RA Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V.,
RA Nester E.W.;
RT "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT C58.";
RL Science 294:2317-2323(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=21608551; PubMed=11743194; DOI=10.1126/science.1066803;
RA Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M.,
RA Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L.,
RA Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F.,
RA Wollam C., Allinger M., Doughty D., Scott C., Lappas C., Markelz B.,
RA Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G.,
RA Cielo C., Slater S.;
RT "Genome sequence of the plant pathogen and biotechnology agent
RT Agrobacterium tumefaciens C58.";
RL Science 294:2323-2328(2001).
Feature:
CHAIN 1 904 DNA mismatch repair protein mutS.
/FTId=PRO_0000115062.
NP_BIND 655 662 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 904
MTDVLTTASL ISEESRATAT PMMEQYIEIK ANNPGSLLFY RMGDFYELFF DDAVEASRAL
GITLTKRGQH MGHDIPMCGV PVHAADDYLQ KLILRGYRVA VCEQIEDPAE AKKRGSKSVV
KRDVVRLVTP GTLTEEKLLS PTESNYLMAL ARIRGSAEAQ FALAWIDIST GVFRLAETTL
TRLLADIWRI DPRELIVADS LFHDEELRPV FDVLGRVAVP QPAILFDSAV AEGRIARYFN
VSTLDGFGTF SRVEMAAAAA AVAYVEKTQI AERPPLGAPE RESAASTLFI DPATRANLEL
VKTLSGDRDG SLLHALNRTV TGGGARLLAE RLMSPLTDPE RINARLDAVA YLIDDVSLCD
GLRDALKHVA DMPRALSRLA LERGGPRDLG AIRQGLVSAE KIAVILDGGL LPDELAKALR
DLKALPGALE AMLGSMLADD LPLLKRDGGF LREGANPELD EVRALRDQSR RVIAGLQLQY
ADETGIKSLK IKHNNVLGYF IEVTAGNADV MMATDEAKAR FIHRQTMAGA MRFTTTELAD
LESRIANAAA EALTMELEAF ERMVEAVVQQ AEAIKAGALA LAVIDVASSL AYLATEQAYC
RPIVDASMTF SIKGGRHPVV EQALRRQSAG PFIANNCDLS AVNGGKNGAI WLLTGPNMGG
KSTFLRQNAL IAILAQIGSF VPAEAAHIGV VDRLFSRVGA SDDLARGRST FMVEMVETAA
ILNQATDRSL VILDEIGRGT ATFDGLSIAW AAVEHLHEVN RCRGLFATHF HELTVLSEKL
GRLSNATMRV KEWEGDVIFL HEVGPGAADR SYGIQVARLA GLPASVVERA REVLTKLEDA
DRKNPASQLI DDLPLFQIAV RREETRKAGP SKVEEALKSF NPDEMTPREA LDALYALKKE
LGKA