|
|
|
|
|
|
Description:
Holliday junction ATP-dependent DNA helicase ruvA (EC 3.6.1.-).
Molecular weight: 21320
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
01-JUN-2002, sequence version 1.
07-MAR-2006, entry version 31.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rhizobiales Rhizobiaceae Agrobacterium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVA_AGRT5:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE009303 | AAL44533.1 | - |
| EMBL | AE008311 | AAK89682.1 | - |
| PIR | AG3014 | AG3014. | |
| PIR | H98269 | H98269. | |
| HSSP | P08576 | 1CUK | |
| GenomeReviews | AE007870_GR | AGR_L_2223.1 | |
| GenomeReviews | AE008689_GR | Atu3723.1 | |
| HAMAP | MF_00031 | - | 1. |
| InterPro | IPR012340 | OB_NA_bd_sub. | |
| InterPro | IPR000085 | RuvA. | |
| InterPro | IPR011114 | RuvA_C. | |
| Pfam | PF07499 | RuvA_C | 1. |
| Pfam | PF01330 | RuvA_N | 1. |
| ProDom | PD006268 | RuvA | 1. |
| TIGRFAMs | TIGR00084 | ruvA | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=21608550; PubMed=11743193; DOI=10.1126/science.1066804;
RA Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P.,
RA Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L.,
RA Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr.,
RA Chapman P., Clendenning J., Deatherage G., Gillet W., Grant C.,
RA Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A.,
RA Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D.,
RA Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M.,
RA Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M.,
RA Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V.,
RA Nester E.W.;
RT "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT C58.";
RL Science 294:2317-2323(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=21608551; PubMed=11743194; DOI=10.1126/science.1066803;
RA Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M.,
RA Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L.,
RA Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F.,
RA Wollam C., Allinger M., Doughty D., Scott C., Lappas C., Markelz B.,
RA Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G.,
RA Cielo C., Slater S.;
RT "Genome sequence of the plant pathogen and biotechnology agent
RT Agrobacterium tumefaciens C58.";
RL Science 294:2323-2328(2001).
Feature:
CHAIN 1 205 Holliday junction ATP-dependent DNA
helicase ruvA.
/FTId=PRO_0000094597.
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing. RuvA stimulates, in the presence of DNA, the weak
ATPase activity of ruvB (By similarity).
-!- SUBUNIT: Forms a complex with ruvB.
-!- SIMILARITY: Belongs to the ruvA family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 205
MIGKLKGSIE EIGADYVLVD VHGVCYVAYC SARTLSKIGS VGEAVVLFIE TYVREDQLKL
FGFVSALERE WFNLLQSVQG VGSKVALAVL STLSPSELAN AIALQDKTMI SRAPGIGPKV
AVRLVTELRN KAPAFAGDAS ASIGLKQELG EGVASAPVAD AVSALTNLGY SRDQAANAVA
AALKNGGEGG DSAKLIRLGL KELSR