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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10703
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
31-OCT-2003, sequence version 2.
07-MAR-2006, entry version 25.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rhizobiales Rhizobiaceae Agrobacterium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_AGRT5:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE009110 | AAL42518.1 | - |
| EMBL | AE008075 | AAK87304.1 | ALT_INIT |
| PIR | AH2762 | AH2762. | |
| PIR | G97543 | G97543. | |
| GenomeReviews | AE007869_GR | AGR_C_2790.1 | |
| GenomeReviews | AE008688_GR | Atu1513.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 1. |
| ProDom | PD000006 | ABC_transporter | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=21608550; PubMed=11743193; DOI=10.1126/science.1066804;
RA Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P.,
RA Okura V.K., Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L.,
RA Chen Y., Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr.,
RA Chapman P., Clendenning J., Deatherage G., Gillet W., Grant C.,
RA Kutyavin T., Levy R., Li M.-J., McClelland E., Palmieri A.,
RA Raymond C., Rouse G., Saenphimmachak C., Wu Z., Romero P., Gordon D.,
RA Zhang S., Yoo H., Tao Y., Biddle P., Jung M., Krespan W., Perry M.,
RA Gordon-Kamm B., Liao L., Kim S., Hendrick C., Zhao Z.-Y., Dolan M.,
RA Chumley F., Tingey S.V., Tomb J.-F., Gordon M.P., Olson M.V.,
RA Nester E.W.;
RT "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT C58.";
RL Science 294:2317-2323(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=21608551; PubMed=11743194; DOI=10.1126/science.1066803;
RA Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M.,
RA Qurollo B., Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L.,
RA Houmiel K., Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F.,
RA Wollam C., Allinger M., Doughty D., Scott C., Lappas C., Markelz B.,
RA Flanagan C., Crowell C., Gurson J., Lomo C., Sear C., Strub G.,
RA Cielo C., Slater S.;
RT "Genome sequence of the plant pathogen and biotechnology agent
RT Agrobacterium tumefaciens C58.";
RL Science 294:2323-2328(2001).
Feature:
CHAIN 1 973 UvrABC system protein A.
/FTId=PRO_0000093032.
DOMAIN 286 615 ABC transporter 1.
DOMAIN 630 958 ABC transporter 2.
NP_BIND 34 41 ATP (Potential).
NP_BIND 662 669 ATP (Potential).
ZN_FING 761 787 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 973
MSELKTISIR GAREHNLKGI DLDLPRNKLI VMTGLSGSGK SSLAFDTIYA EGQRRYVESL
SAYARQFLEM MQKPDVDQID GLSPAISIEQ KTTSRNPRST VGTVTEIYDY MRLLFARVGV
PYSPATGLPI ESQTVSQMVD RILAFEEGTR LYILAPIVRG RKGEYKKELA ELMKKGFQRV
KVDGQFYEIA DVPALDKKYK HDIDVVVDRA VVRPDMAARL ADSLETCLKL ADGLAIAEFA
DKPLPPEDTA AGGSANKSLN ETHERVLFSE KFACPVSGFT IPEIEPRLFS FNNPFGACPS
CDGLGSQQKV DENLIVPEPA RTLRDGAIAP WAKSSSPYYN QTLEALGKAF GFKLSSKWTD
LSKEAQHAIL QGTDDKIEFN YQDGARSYKT VKNFEGIVPN LERRWKETDS AWAREEIERY
MSAAPCPACA GYRLKPEALA VKINKLHIGE VTQMSIRKAR DWFEVLPENL NAKQNEIAVR
ILKEIRERLR FLNDVGLDYL SLSRNSGTLS GGESQRIRLA SQIGSGLTGV LYVLDEPSIG
LHQRDNARLL ETLKHLRDIG NTVIVVEHDE DAILTADYVV DIGPAAGIHG GQVIAEGTPQ
DVMANPKSLT GKYLSGELGV AVPAERRKPK KGREIKVFGA RGNNLQNVTA AVPLGVFTAV
TGVSGGGKST FLIETLYKSA ARRVMGAREI PAEHDRIDGF EFIDKVIDID QSPIGRTPRS
NPATYTGAFT PIRDWFAGLP EAKARGYAPG RFSFNVKGGR CEACQGDGVI KIEMHFLPDV
YVTCDVCHGK RYNRETLDVT FKGKSIADVL DMTVEEGVEF FAAVPAVRDK LQSLFDVGLG
YIKVGQQANT LSGGEAQRVK LAKELSKRST GRTLYILDEP TTGLHFHDVN KLLEMLHALV
EQGNSVVVIE HNLEVIKTAD WIIDIGPEGG TGGGEVVATG TPEDIVKVER SYTGHFLKEL
LDRRPAGKRE AAE