Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 24655
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
07-MAR-2006, entry version 32.
Phylogenetic order:
Bacteria Actinobacteria Actinobacteridae Actinomycetales Corynebacterineae Mycobacteriaceae Mycobacterium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_MYCLE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL583923 | CAC30628.1 | - |
| PIR | E87118 | E87118. | |
| HSSP | P12295 | 1FLZ | |
| GenomeReviews | AL450380_GR | ML1675.1 | |
| Leproma | ML1675 | -. | |
| BioCyc | MLEP1769:ML1675-MONOMER | -.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR003250 | U_glycsylse_pox. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| ProDom | PD011327 | U_glycsylse_pox | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX MEDLINE=21128732; PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
Feature:
CHAIN 1 227 Uracil-DNA glycosylase.
/FTId=PRO_0000176118.
ACT_SITE 68 68 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 227
MTARPLSELV EQGWAAALEP VVDQVAEMGR FLRAEIAAGR RYLPAGHSVL RAFTYPFDNV
RVLIVGQDPY PTPGHAVGLS FSVAPDVRPL PRSLANVFDE YTADLGYPLP VCGDLTPWAQ
RGVLLLNRVL TVRPSNPASH RGKGWEVITE CAIRALAARS EPMVAILWGR DAATLKPLLT
VDNCVVIESP HPSPLSASRG FFGSRPFSRT NEILVGMGAG PINWRLP