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Description:
Regulatory protein recX.
Molecular weight: 19146
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
regulation of DNA repair( GO:0006282 )
Important dates:
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
15-MAR-2005, sequence version 1.
07-MAR-2006, entry version 6.
Phylogenetic order:
Bacteria Actinobacteria Actinobacteridae Actinomycetales Corynebacterineae Mycobacteriaceae Mycobacterium Mycobacterium tuberculosis complex.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECX_MYCTU:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BX842580 | CAA15532.1 | - |
| EMBL | AE000516 | AAK47126.1 | ALT_INIT |
| PIR | G70877 | G70877. | |
| GenomeReviews | AE000516_GR | MT2805.1 | |
| GenomeReviews | AL123456_GR | Rv2736c.1 | |
| TIGR | MT2805 | -. | |
| TubercuList | Rv2736c | -. | |
| HAMAP | MF_01114 | - | 1. |
| InterPro | IPR003783 | RecX. | |
| Pfam | PF02631 | RecX | 1. |
Keywords:
Complete proteome; Direct protein sequencing.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H37Rv;
RX MEDLINE=98295987; PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
RA Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
RA Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
RA Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
RA Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
RA Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
RA Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the
RT complete genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX MEDLINE=22206494; PubMed=12218036;
RX DOI=10.1128/JB.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H.,
RA Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D.,
RA Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M.,
RA Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C.,
RA Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
RN [3]
RP PROTEIN SEQUENCE OF 1-10, AND CHARACTERIZATION.
RX MEDLINE=22223026; PubMed=12218174; DOI=10.1073/pnas.192178999;
RA Venkatesh R., Ganesh N., Guhan N., Reddy M.S., Chandrasekhar T.,
RA Muniyappa K.;
RT "RecX protein abrogates ATP hydrolysis and strand exchange promoted by
RT RecA: insights into negative regulation of homologous recombination.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:12091-12096(2002).
Feature:
CHAIN 1 174 Regulatory protein recX.
/FTId=PRO_0000162450.
Comments:
-!- FUNCTION: Binds to recA inhibiting ATP hydrolysis and the
generation of heteroduplex DNA. It might act as an anti-
recombinase to quell inappropriate recombinational repair during
normal DNA metabolism. It is essential for cell survival.
-!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
-!- SIMILARITY: Belongs to the recX family.
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Sequence length: 174
MTVSCPPPST SEREEQARAL CLRLLTARSR TRAELAGQLA KRGYPEDIGN RVLDRLAAVG
LVDDTDFAEQ WVQSRRANAA KSKRALAAEL HAKGVDDDVI TTVLGGIDAG AERGRAEKLV
RARLRREVLI DDGTDEARVS RRLVAMLARR GYGQTLACEV VIAELAAERE RRRV