Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 26288
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
07-MAR-2006, entry version 21.
Phylogenetic order:
Bacteria Firmicutes Bacillales Bacillaceae Oceanobacillus.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_OCEIH:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000028 | BAC14085.1 | - |
| HSSP | P12295 | 1LQJ | |
| GenomeReviews | BA000028_GR | OB2129.1 | |
| BioCyc | OIHE182710:OB2129-MONOMER | -.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTE831 / DSM 14371 / JCM 11309;
RX MEDLINE=22220767; PubMed=12235376; DOI=10.1093/nar/gkf526;
RA Takami H., Takaki Y., Uchiyama I.;
RT "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya
RT Ridge and its unexpected adaptive capabilities to extreme
RT environments.";
RL Nucleic Acids Res. 30:3927-3935(2002).
Feature:
CHAIN 1 229 Uracil-DNA glycosylase.
/FTId=PRO_0000176123.
ACT_SITE 65 65 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 229
MENPLYNDWS LLLEDEFKKD YYLRLRSFLK KEYTEEKIHP AMEDIFNALH FTPFHKVKVV
ILGQDPYHGP DQAHGLSFSV QPGITIPPSL KNIFKELTHE FGMSMPTHGH LTHWAKQGVL
LLNNVLTVRE GKAHSHRGQG WEVFTDKVIQ TLNQKDHPVV FLLWGGAAQK KGELIDTNKH
IILKAPHPSP LSAYRGFFES NHFSKANQIL HKNNVEEIDW TLPESPSQG