Description:
Endonuclease V (EC 3.1.21.7) (Deoxyinosine 3'endonuclease)(Deoxyribonuclease V) (DNase V).
Molecular weight: 26143
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
07-MAR-2006, entry version 15.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Xanthomonadales Xanthomonadaceae Xylella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein NFI_XYLFT:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE009442 | AAO28764.1 | - |
| GenomeReviews | AE009442_GR | PD0899.1 | |
| BioCyc | XFAS183190:PD0899-MONOMER | -.1 | |
| HAMAP | MF_00801 | - | 1. |
| InterPro | IPR007581 | Endonuc_V. | |
| Pfam | PF04493 | Endonuclease_5 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Endonuclease; Hydrolase; Magnesium; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=22421331; PubMed=12533478;
RX DOI=10.1128/JB.185.3.1018-1026.2003;
RA Van Sluys M.A., de Oliveira M.C., Monteiro-Vitorello C.B.,
RA Miyaki C.Y., Furlan L.R., Camargo L.E.A., da Silva A.C.R., Moon D.H.,
RA Takita M.A., Lemos E.G.M., Machado M.A., Ferro M.I.T., da Silva F.R.,
RA Goldman M.H.S., Goldman G.H., Lemos M.V.F., El-Dorry H., Tsai S.M.,
RA Carrer H., Carraro D.M., de Oliveira R.C., Nunes L.R., Siqueira W.J.,
RA Coutinho L.L., Kimura E.T., Ferro E.S., Harakava R., Kuramae E.E.,
RA Marino C.L., Giglioti E., Abreu I.L., Alves L.M.C., do Amaral A.M.,
RA Baia G.S., Blanco S.R., Brito M.S., Cannavan F.S., Celestino A.V.,
RA da Cunha A.F., Fenille R.C., Ferro J.A., Formighieri E.F., Kishi L.T.,
RA Leoni S.G., Oliveira A.R., Rosa V.E. Jr., Sassaki F.T., Sena J.A.D.,
RA de Souza A.A., Truffi D., Tsukumo F., Yanai G.M., Zaros L.G.,
RA Civerolo E.L., Simpson A.J.G., Almeida N.F. Jr., Setubal J.C.,
RA Kitajima J.P.;
RT "Comparative analyses of the complete genome sequences of Pierce's
RT disease and citrus variegated chlorosis strains of Xylella
RT fastidiosa.";
RL J. Bacteriol. 185:1018-1026(2003).
Feature:
CHAIN 1 239 Endonuclease V.
/FTId=PRO_0000159680.
Comments:
-!- FUNCTION: Selectively cleaves double-stranded DNA at the second
phosphodiester bond 3' to a deoxyinosine leaving behind the intact
lesion on the nicked DNA. Acts in DNA repair (By similarity).
-!- CATALYTIC ACTIVITY: Endonucleolytic cleavage at apurinic or
apyrimidinic sites to products with a 5'-phosphate.
-!- COFACTOR: Magnesium (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the endonuclease V family.
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Sequence length: 239
MKISSIDSIF AAWDGSITEA RRLQSDMAER IVLKDEPNLL SEPTLLAGFD VGFEDEGRTT
RAAAVLMNAG DLRLLETHVV RVPTSMPYVP GLLSFRELPA LLQALTQLSR IPALVFVDGH
GIAHPRRLGI AAHFGLVTNL PCIGVAKKRL VGDFVEPGTA FGEHTPILLH GTQVGWALRS
KMHCKPLIIS PGHKVSLHSA LTWTQRCLTG YRLPEPTRQA DRLASRRGQK IVSDLPSLL