Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 66294
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
07-MAR-2006, entry version 45.
Phylogenetic order:
Archaea Euryarchaeota Methanobacteria Methanobacteriales Methanobacteriaceae Methanothermobacter.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_METTH:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE000666 | AAB84947.1 | - |
| PIR | F69157 | F69157. | |
| HSSP | P07025 | 1QOJ | |
| GenomeReviews | AE000666_GR | MTH441.1 | |
| BioCyc | MTHE187420:MTH441-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF00633 | HHH | 2. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| SMART | SM00278 | HhH1 | 2. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Delta H;
RX MEDLINE=98037514; PubMed=9371463;
RA Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K.,
RA Harrison D., Hoang L., Keagle P., Lumm W., Pothier B., Qiu D.,
RA Spadafora R., Vicare R., Wang Y., Wierzbowski J., Gibson R.,
RA Jiwani N., Caruso A., Bush D., Safer H., Patwell D., Prabhakar S.,
RA McDougall S., Shimer G., Goyal A., Pietrovski S., Church G.M.,
RA Daniels C.J., Mao J.-I., Rice P., Noelling J., Reeve J.N.;
RT "Complete genome sequence of Methanobacterium thermoautotrophicum
RT deltaH: functional analysis and comparative genomics.";
RL J. Bacteriol. 179:7135-7155(1997).
Feature:
CHAIN 1 579 UvrABC system protein C.
/FTId=PRO_0000138369.
DOMAIN 193 228 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 579
MTRVKDPEKL PDATGVYIFR DRDDRVLYVG KSISIRKRVS SYFREQENPR LRIMMRHLES
IEYILTQNEK EALILESNLI KRYRPPYNVR LKDDKRYPFI KITDEEYPRV LIVRTIGRDS
ARYYGPFTDT GAVRRTLKLI KSLFRIRSCR RMDGPCLNSQ IDLCYAPCDG RISREDYREI
IEKVDLFFQG RYQEVIEVLE EEMKEASERL EFERAARIRD QIESIREVME RQHASFTDSI
DQDIVALERG GDTSAVVVLQ IRDGKITGKD DFILRGSAPR TEILEAFLKQ YYAIPRRVPS
EILTQYPVED GVIAEWLSEL RGEEVKIHSP EGGAGRRLLN IAWKNASVIL KQKGRVRDAL
LQLKDDLKLP EIPRRMEGLD ISNIAGESAT GSVAVFIDGK PSSGSYRRYR ISAQGPDDYA
MMRELVERRY SSPELRKPDL VLIDGGKGQL GVALEALKNC GVHVPVVGIA KKREEVYLPG
LSEPVDVDDG ALQILRHLRD EAHRFAVKYH RTIRDRDSLE SELDGIRGVG PVRKRALLEH
FGSLDGVRDA SVEELASIPG MTREVAERIH RHFSGDLAG