Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 80841
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
07-MAR-2006, entry version 45.
Phylogenetic order:
Bacteria Actinobacteria Actinobacteridae Actinomycetales Streptomycineae Streptomycetaceae Streptomyces.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_STRCO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL939110 | CAB38143.1 | - |
| PIR | T36026 | T36026. | |
| GenomeReviews | AL645882_GR | SCO1953.1 | |
| BioCyc | SCOE1902:SCO1953-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR000445 | HhH. | |
| InterPro | IPR003583 | HHH1_bd. | |
| InterPro | IPR001943 | UvrB/C. | |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| Pfam | PF00633 | HHH | 1. |
| Pfam | PF02151 | UVR | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| SMART | SM00278 | HhH1 | 2. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50151 | UVR | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A3(2) / M145;
RX MEDLINE=21996410; PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H.,
RA Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M.,
RA Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S.,
RA Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S.,
RA Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S.,
RA Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K.,
RA Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J.,
RA Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces
RT coelicolor A3(2).";
RL Nature 417:141-147(2002).
Feature:
CHAIN 1 728 UvrABC system protein C.
/FTId=PRO_0000138345.
DOMAIN 208 243 UVR.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
-!- SIMILARITY: Contains 1 UVR domain.
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Sequence length: 728
MADPSSYRPR PGEIPDSPGV YRFRDEHRRV IYVGKAKSLR QRLANYFQDL AHLHPRTRTM
VTTAASVEWT VVSTEVEALQ LEYSWIKEYD PRFNVKYRDD KSYPYLAVTM NEEFPRVQVM
RGQKKKGVRY FGPYGHAWAI RDTVDLLLRV FPVRTCSAGV FKNAARTGRP CLLGYIGKCS
APCVGRITPD DHWDLADEFC DFMAGRTGTY LRRLERQMAE AAEEMEYERA ARLRDDIGAL
KKAMEKSAVV LADATDADLI AVAEDELEAA VQIFHVRGGR VRGQRGWVTD KVEEITTGAL
VEHALQQLYG EEKGDAVPKE VLVPALPDPV EPVQQWLAER RGSGVSLRIP QRGDKKALME
TVQRNAQQAL VLHKTKRASD LTTRSRALEE IAEALDLDSA PLRIECYDIS HLQGDDVVAS
MVVFEDGLAR KSEYRRFQIK GFEGQDDVRS MHEVITRRFR RYLAEKERTG EWADGEGLVD
DARHPNGDAA PNGDAAPNDG AAPDDGAART DGRGLTDGQE LTDGPALKDD DGRPKRFAYP
PQLVVVDGGQ PQVAAAQRAL DELGIDDIAV CGLAKRLEEV WLPREDDPVV LPRTSEGLYL
LQRVRDEAHR FAITYQRAKR AKRFRAGPLD DVPGLGETRK QALIKHFGSV KKLRSATIDQ
ICEVPGIGRK TAETVAVALA RATPAAPAVN TATGEIMDDD DGAPETTADA PGEPVSAGTP
DERRGQER