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Description:
Holliday junction ATP-dependent DNA helicase ruvB (EC 3.6.1.-).
Molecular weight: 37312
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
03-APR-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
07-MAR-2006, entry version 29.
Phylogenetic order:
Bacteria Proteobacteria Epsilonproteobacteria Campylobacterales Campylobacteraceae Campylobacter.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVB_CAMJE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL139078 | CAB73789.1 | - |
| PIR | G81280 | G81280. | |
| HSSP | Q56313 | 1IN5 | |
| GenomeReviews | AL111168_GR | Cj1362.1 | |
| BioCyc | CJEJ192222:CJ1362-MONOMER | -.1 | |
| HAMAP | MF_00016 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003959 | AAA_ATPase_centr. | |
| InterPro | IPR004605 | RuvB. | |
| InterPro | IPR008823 | RuvB_C. | |
| InterPro | IPR008824 | RuvB_N. | |
| InterPro | IPR011991 | Wing_hlx_DNA_bd. | |
| Pfam | PF00004 | AAA | 1. |
| Pfam | PF05491 | RuvB_C | 1. |
| Pfam | PF05496 | RuvB_N | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00635 | ruvB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 11168;
RX MEDLINE=20150912; PubMed=10688204; DOI=10.1038/35001088;
RA Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W.,
RA Quail M.A., Rajandream M.A., Rutherford K.M., van Vliet A.H.M.,
RA Whitehead S., Barrell B.G.;
RT "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT reveals hypervariable sequences.";
RL Nature 403:665-668(2000).
Feature:
CHAIN 1 335 Holliday junction ATP-dependent DNA
helicase ruvB.
/FTId=PRO_0000165510.
NP_BIND 59 66 ATP (Potential).
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing (By similarity).
-!- SUBUNIT: Forms a complex with ruvA (By similarity).
-!- SIMILARITY: Belongs to the ruvB family.
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Sequence length: 335
MDRIVEIEKY SFDETYETSL RPSNFDGYIG QESIKKNLNV FIAAAKKRNE CLDHILFSGP
AGLGKTTLAN IISYEMSANI KTTAAPMIEK SGDLAAILTN LSEGDILFID EIHRLSPAIE
EVLYPAMEDY RLDIIIGSGP AAQTIKIDLP KFTLIGATTR AGMLSNPLRD RFGMQFRLEF
YKDSELALIL QKAALKLNKT CEEKAALEIA KRSRSTPRIA LRLLKRVRDF ADVNDEEIIT
EKRANEALNS LGVNELGFDA MDLRYLELLT AAKQKPIGLA SIAAALSEDE NTIEDVIEPY
LLANGYIERT AKGRIASAKS YSALKLNYEK TLFEE