Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 25457
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
11-OCT-2004, sequence version 1.
07-MAR-2006, entry version 11.
Phylogenetic order:
Bacteria Actinobacteria Actinobacteridae Actinomycetales Micrococcineae Cellulomonadaceae Tropheryma.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_TROWT:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE016852 | AAO44679.1 | - |
| HSSP | P13051 | 1EMH | |
| GenomeReviews | AE014184_GR | TWT582.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR003250 | U_glycsylse_pox. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| ProDom | PD011327 | U_glycsylse_pox | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX MEDLINE=22784088; PubMed=12902375; DOI=10.1101/gr.1474603;
RA Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M.,
RA Claverie J.-M.;
RT "Tropheryma whipplei Twist: a human pathogenic Actinobacteria with a
RT reduced genome.";
RL Genome Res. 13:1800-1809(2003).
Feature:
CHAIN 1 230 Uracil-DNA glycosylase.
/FTId=PRO_0000176158.
ACT_SITE 71 71 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 230
MGYLHVLAQR GVIHATWVSA LEPVSSNLAA MGDCLRSLRS KGESFLPAPR NILRAFRYPF
DSVRVLIVGQ DPYPTQGHPI GLSFAVDHKV RPLPGSLQNI YTEYRSDLNL DPPQHGDISL
WSERGVMLLN RTLTVRPGIP SSHRGLGWEE ITQTAVRALA ARDVPLIAIL WGRHAQELKS
VLQSDRVAIL ESVHPSPMSA TRGFFGSKPF SKANDLLRDL GSAPIDWRLT