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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10633
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 2.
07-MAR-2006, entry version 45.
Phylogenetic order:
Bacteria Firmicutes Mollicutes Mycoplasmataceae Mycoplasma.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_MYCGE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | L43967 | AAC71645.1 | ALT_INIT |
| EMBL | U02172 | AAD12454.1 | ALT_INIT |
| EMBL | X61514 | CAA43728.1 | - |
| PIR | T09750 | T09750. | |
| HSSP | P58301 | 1F2T | |
| GenomeReviews | L43967_GR | MG421.1 | |
| TIGR | MG421 | -. | |
| BioCyc | MGEN2097:MG421-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 1. |
| ProDom | PD000006 | ABC_transporter | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / G-37;
RX MEDLINE=96026346; PubMed=7569993;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-85.
RC STRAIN=ATCC 33530 / G-37;
RX MEDLINE=94075230; PubMed=8253680;
RA Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A survey of the Mycoplasma genitalium genome by using random
RT sequencing.";
RL J. Bacteriol. 175:7918-7930(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 569-668.
RC STRAIN=ATCC 33530 / G-37;
RX MEDLINE=92051396; PubMed=1945886;
RA Peterson S.N., Schramm N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A random sequencing approach for placing markers on the physical map
RT of Mycoplasma genitalium.";
RL Nucleic Acids Res. 19:6027-6031(1991).
Feature:
CHAIN 1 952 UvrABC system protein A.
/FTId=PRO_0000093064.
DOMAIN 244 601 ABC transporter 1.
DOMAIN 615 943 ABC transporter 2.
NP_BIND 38 45 ATP (Potential).
ZN_FING 259 286 C4-type.
NP_BIND 647 654 ATP (Potential).
ZN_FING 746 772 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 952
MKPEWKNNDF IRVKGARENN LKNINIDIPK NQFVVITGLS GSGKSSLAFN TIYAEGRRRY
LESLSSYARQ FLGNSDKPDV DLIEGLSPAI SIDQKTTSHN PRSTMGTVTE IYDYLRLLWA
RIGTPYCPNG HGSIQTQTIN QIANQIFDLP NKSKVQLLAP TVKNQRGIFT NEFIKYKQLG
FLRVLVDGQI YTLDDEIKLD KNTKHNISVV IDRIIINKDN QTYSRIVDSI ETIDRLTNGK
IEVLKEDGTI LNFSKNHGCD KCGFSISELE PRLFSFNSPL GSCSYCKGLG FSYEPDVDKI
IADSKLSINQ GAIDIFKNIV HGTSLDWQRF LSLVNHYKIP LDKPIEQLDK SQLNLILEGS
DEPIEIKTIS NSGAKNIRFE HYEGIANLIK RRHLETNSQV SREWYSAYMS EITCKKCHGK
KLIKDALSVK LGGIDIISFT ELSIDKSIDF LLKLELNDEQ KKIGELALKE IINRLSFLKN
VGLDYLNLAR RASTLSGGEA QRIRLATQIG SQLTGVLYVM DEPSIGLHQK DNMRLIKTMM
VMRDLGNTLL VVEHDSETML AADYLIDIGP KAGNEGGELV ACGTPLQVME NSNSITGQYL
SGKKQISIPK NRHSGNGKTI IIKGAKVNNL KNINVTIPLN KLVLITGVSG SGKSSLINQT
LVPALERILY RKGVKKDTYK EIIGANNIDK IIVVSQDPIG RTPRSNPATY ISVFDDIRDL
FANTKEAKAR GYTNSRFSFN VPGGRCDKCF GDGVIRIEMH FLPDVYVKCE VCNGKKYNSQ
TLEIKYLGKS IFDVLQMSCK EAYEFFKAIP NISRKLRLLC DVGLEYLQLG INVTFLSGGE
AQRIKLSKFL QKKSTGKTLF VLDEPSTGLH LEDINKLLTI IQRIIKNGDT VVVIEHNLDI
IKVADYIIDL GPEGGDNGGQ IVAQGTPEQL INQVNKSYTA QYLSKILKPD SI