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Description:
UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C).
Molecular weight: 68696
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 2.
07-MAR-2006, entry version 36.
Phylogenetic order:
Bacteria Firmicutes Mollicutes Mycoplasmataceae Mycoplasma.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRC_MYCGE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | L43967 | AAC71424.1 | - |
| EMBL | U02182 | AAD12468.1 | - |
| PIR | T09715 | T09715. | |
| GenomeReviews | L43967_GR | MG206.1 | |
| TIGR | MG206 | -. | |
| BioCyc | MGEN2097:MG206-MONOMER | -.1 | |
| HAMAP | MF_00203 | - | 1. |
| InterPro | IPR004791 | UvrC_ABC. | |
| InterPro | IPR001162 | UvrC_C. | |
| InterPro | IPR000305 | UvrC_N. | |
| Pfam | PF01541 | GIY-YIG | 1. |
| ProDom | PD005870 | UvrC_C | 1. |
| SMART | SM00465 | GIYc | 1. |
| TIGRFAMs | TIGR00194 | uvrC | 1. |
| PROSITE | PS50164 | UVRC_1 | 1. |
| PROSITE | PS50165 | UVRC_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA excision; DNA repair; Excision nuclease; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / G-37;
RX MEDLINE=96026346; PubMed=7569993;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 299-383.
RC STRAIN=ATCC 33530 / G-37;
RX MEDLINE=94075230; PubMed=8253680;
RA Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A survey of the Mycoplasma genitalium genome by using random
RT sequencing.";
RL J. Bacteriol. 175:7918-7930(1993).
Feature:
CHAIN 1 597 UvrABC system protein C.
/FTId=PRO_0000138317.
CONFLICT 370 383 HKDLAQLLNTDYIH -> QQGFSTTSKYWLYP (in Ref.
2).
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrC both incises the 5' and 3' sides
of the lesion. The N-terminal half is responsible for the 3'
incision and the C-terminal half is responsible for the 5'
incision (By similarity).
-!- SUBUNIT: Interacts with uvrB in an incision complex (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uvrC family.
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Sequence length: 597
MTTNLKQKLK TAPKKPGCYL WKDSNGKVLY VGKASNIFNR VHQYFQKNNP YKTQLLSSQI
SDVDFFILKD ENDALNLEAK LINQYQPRFN LVLKQNNGYL YFYITKAKKP TLELARKYQI
KTTKCFGPFA SSKFKLREIH DLLLKLFPLR KCAPHQKNHP CFYFQMGLCM GQCMQTDTKE
KYQQVISNIE QFFNDPSVVI NYLKAAEKKA SDNQEFEKAQ QFLTLQKAVL ELTKTHHTTI
IKQKSSHDFI GYVFQNNVLA ITIFCYEKGE LTDKEQAVFT LEQTDIVEVE SAIITFIYHH
YKTTPLPSKI TVSLDETNLK LISDSLKIGV FKPKNGNEKL ILQTVIDNAK HALATKWLKF
TSNYDKTQLH KDLAQLLNTD YIHSLEIIDV SFYDQNHVVG CMLRFEDGKK IKHLSRRYNI
NSLKKGDTNH IALLVYRRIL SAMQTKANLP FSDLLIIDGG KAQIKSVKQV FSLFSNVKPP
IIIGLVKNKN HQTDHIMLSD FQVKKIAINS PLFHYLATIQ TEVDGFAKRS AFNKLSNHQL
QNPLLQIPGV GKITAQILFD NFQTLNNIKL ASVNELSQFI KKPLAQKIKT YFAKQTD